Front Cover: De Novo Design of Selective Quadruplex–Duplex Junction Ligands and Structural Characterisation of Their Binding Mode: Targeting the G4 Hot‐Spot (Chem. Eur. J. 20/2021)

Abstract

The structural motif defined by a G‐quadruplex DNA juxtaposed to duplex regions has been identified as a hot‐spot for molecular recognition, and selectively targeted by a family of benzylamine‐containing derivatives. The understanding of this new mode of interaction was uncovered by the structural dissection of both ligand and receptor contributions. More information can be found in the Full Paper by A. G. Santana, C. González, J. L. Asensio, et al. on page 6204.