From precursors to myelinating oligodendrocytes: Contribution of intrinsic and extrinsic factors to white matter plasticity in the adult brain

Boulanger, Jenna J.; Messier, Claude

doi:10.1016/j.neuroscience.2014.03.063

Cited by 77 publications

(70 citation statements)

References 329 publications

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“…Nervous system repair and brain plasticity throughout adult life depend on the function of neural progenitor cells that reside throughout the brain, in white matter tracts, and in specialized neurovascular niches (1)(2)(3)(4)(5). Understanding the cellular and molecular factors that orchestrate progenitor cell function is critically important for developing strategies that maintain CNS function and for promoting tissue repair after injury (6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Bone marrow drives central nervous system regeneration after radiation injury

Dietrich

Baryawno

Nayyar

et al. 2017

Journal of Clinical Investigation

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Section: Introductionmentioning

confidence: 99%

Bone marrow drives central nervous system regeneration after radiation injury

Dietrich

Baryawno

Nayyar

et al. 2017

Journal of Clinical Investigation

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“…Differentiation of oligodendrocyte precursor cells into myelinating oligodendrocytes can be defined in 7 stages (Boulanger and Messier, 2014). Using the immunofluorescence method, we found that LINGO-1 and WNK1 were expressed in enriched cultures of oligodendrocytes at early (NG2 or A2B5 positive pre-oligodendrocytes) or late developmental stages (O4 positive immature oligodendrocytes, MBP positive nonmyelinating mature oligodendrocytes) ( Fig.…”

Section: Lingo-1 and Wnk1 Are Both Expressed In Oligodendrocytes And mentioning

confidence: 92%

WNK1 is involved in Nogo66 inhibition of OPC differentiation

Zhang

Wang

et al. 2015

Molecular and Cellular Neuroscience

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“…Oligodendrocytes are the myelin-producing cells of the CNS, and as such, wrap layers of lipid-dense insulating myelin around axons (Boulanger & Messier, 2014). In a myelinated axon the voltage gated sodium channels are found clustered at short myelin-free segments termed nodes of Ranvier.…”

Section: Introductionmentioning

confidence: 99%

Behavioral experiences as drivers of oligodendrocyte lineage dynamics and myelin plasticity

2016

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Many behavioral experiences are known to promote hippocampal neurogenesis. In contrast, the ability of behavioral experiences to influence the production of oligodendrocytes and myelin sheath formation remains relatively unknown. However, several recent studies indicate that voluntary exercise and environmental enrichment can positively influence both oligodendrogenesis and myelination, and that, in contrast, social isolation can negatively influence myelination. In this review we summarize studies addressing the influence of behavioral experiences on oligodendrocyte lineage cells and myelin, and highlight potential mechanisms including experience-dependent neuronal activity, metabolites, and stress effectors, as well as both local and systemic secreted factors. Although more study is required to better understand the underlying mechanisms by which behavioral experiences regulate oligodendrocyte lineage cells, this exciting and newly emerging field has already revealed that oligodendrocytes and their progenitors are highly responsive to behavioral experiences and suggest the existence of a complex network of reciprocal interactions among oligodendrocyte lineage development, behavioral experiences, and brain function. Achieving a better understanding of these relationships may have profound implications for human health, and in particular, for our understanding of changes in brain function that occur in response to experiences. This article is part of the Special Issue entitled 'Oligodendrocytes in Health and Disease'.

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From precursors to myelinating oligodendrocytes: Contribution of intrinsic and extrinsic factors to white matter plasticity in the adult brain

Cited by 77 publications

References 329 publications

Bone marrow drives central nervous system regeneration after radiation injury

Bone marrow drives central nervous system regeneration after radiation injury

WNK1 is involved in Nogo66 inhibition of OPC differentiation

Behavioral experiences as drivers of oligodendrocyte lineage dynamics and myelin plasticity

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