From Peruvian mummies to living humans: first case of pulmonary tuberculosis caused by Mycobacterium pinnipedii

Žmak, Ljiljana; Obrovac, Mihaela; Makek, Mateja Janković; Perko, G.; Trkanjec, Jasna Tekavec

doi:10.5588/ijtld.19.0159

Cited by 5 publications

(3 citation statements)

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“…Now is widely accepted that MTB originated in Africa more than 7000 years ago from environmental mycobacteria. With the aid of the establishment of agriculture, livestock, establishment of the civilization and increase of the population density it was possible to select virulent strains and the populations transmitted that [40][41][42][43][44].…”

Section: Mycobacteria and Mycobacterium Tuberculosis: An Interesting ...mentioning

confidence: 99%

The Mycobacterium tuberculosis: A Silent Killer

Oliveira,

Ferreira,

Matta

et al. 2023

Preprint

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Mycobacterium tuberculosis is the agent of tuberculosis, one of the most important infectious diseases in the world. This microorganism stands out from other bacteria, not only for its extremely high infection capacity, but also for its cellular characteristics that include an extremely resistant and hydrophobic cellular parade the passage of antibiotics. An incredible ability to adapt to adverse conditions inside the host as well as its vast arsenal of virulence factors that allow its survival within the inhospitable environment within the macrophage can be highlighted. This review aims to discuss several aspects of MTB microbiology, genetics, and physiology. We will address in this review details of the metabolism of MTB that allows it to replicate in the active phase and remain viable during latency, as well as the characteristics of its cell wall that contribute to the blockade of the immune response and its resistance to antibiotics.

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Section: Mycobacteria and Mycobacterium Tuberculosis: An Interesting ...mentioning

confidence: 99%

The Mycobacterium tuberculosis: A Silent Killer

Oliveira,

Ferreira,

Matta

et al. 2023

Preprint

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“…The first case of tuberculosis reported and described in wild seals occurred in an Australian marine park ( Cousins et al., 1990 ). M. pinnipedii caused infection in several non-marine mammals, including humans, in the context of zoo outbreaks and free-ranging transmission ( Cousins et al., 2003 ; Kiers et al., 2008 ; Moser et al., 2008 ; Loeffler et al., 2014 ; Zmak et al., 2019 ; Macedo et al., 2020 ). Moreover, the contact of wild seals with the habitants from the South American coasts may have facilitated the zoonotic transmission of M. pinnipedii in the pre-Columbian era ( Bos et al., 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Transmissibility of Mycobacterium pinnipedii in a murine model

Marfil,

Blanco,

Colombatti Olivieri

et al. 2024

Front. Cell. Infect. Microbiol.

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The causative agent of tuberculosis in pinnipeds is Mycobacterium pinnipedii, a member of the Mycobacterium tuberculosis complex (MTC). The natural hosts are pinnipeds; however, other non-marine mammals, including humans, can also be infected. The transmissibility of a pathogen is related to its virulence. The transmissibility of a M. pinnipedii strain (i.e., 1856) was investigated in a murine model and compared with that of two Mycobacterium bovis strains (i.e., 534 and 04-303) with different reported virulence. Non-inoculated mice (sentinels) were co-housed with intratracheally inoculated mice. Detailed inspection of mice to search for visible tuberculosis lesions in the lungs and spleen was performed, and bacillus viability at 30, 60, and 90 days post-inoculation (dpi) was assayed. A transmissibility of 100% was recorded at 30 dpi in sentinel mice co-housed with the inoculated mice from the M. pinnipedii and M. bovis 04-303 groups, as evidenced by the recovery of viable M. pinnipedii and M. bovis from the lungs of sentinel mice. Mice inoculated with M. pinnipedii (1856) and M. bovis (534) survived until euthanized, whereas five of the M. bovis 04-303-inoculated mice died at 17 dpi. This study constitutes the first report of the transmissibility of a M. pinnipedii strain in mice and confirms the utility of this experimental model to study virulence features such as the transmission of poorly characterized MTC species.

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“…Its main hosts are pinnipeds, but has been also detected from other marine-and non-marine organisms (Kiers et al, 2008;Roe et al, 2019;Macedo et al, 2020). Human infection cases were also described, however, they are extremely rare and some of the reports might be questionable (Kiers et al, 2008;Zmak et al, 2019;Macedo et al, 2020).…”

Section: Overview Of the M Tuberculosis Complexmentioning

confidence: 99%

Development of lipid biomarker based diagnostic method for TB research in archaeological samples via HPLC-HRMS

Váradi

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From Peruvian mummies to living humans: first case of pulmonary tuberculosis caused by Mycobacterium pinnipedii

Cited by 5 publications

References 0 publications

The <em>Mycobacterium tuberculosis</em>: A Silent Killer

The <em>Mycobacterium tuberculosis</em>: A Silent Killer

Transmissibility of Mycobacterium pinnipedii in a murine model

Development of lipid biomarker based diagnostic method for TB research in archaeological samples via HPLC-HRMS

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