2023
DOI: 10.1021/acs.langmuir.3c01817
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From Nanovesicles to Nanobubbles Based on Repeated Compression Method

Tiandong Chen,
Weiling Miao,
Zhenrong Yang
et al.

Abstract: Nanobubbles have been increasingly applied in biomedicine, which is attributed to their ability to work as ultrasound imaging contrast agents and powerful gene/drug carriers. Different production techniques or approaches have been developed to generate uniform and stable shelled nanobubbles. However, these shelled nanobubbles are usually prepared based on disordered shell materials, such as free phospholipids and polymers. In recent years, the continuous repeated compression method for a gas−liquid mixture has… Show more

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“…To overcome this drawback, encapsulated micro-nanobubbles which consist of a gas core and an external membrane shell were adequately studied in previous works. In particular, three kinds of materials (i.e., proteins, lipids, and polymers , ) usually act as the membrane shell materials to stabilize the MNBs and provide them biocompatibility and echogenicity. Among the materials, lipids are the most widely used due to their safety, high stability, good biocompatibility, and ease of chemical surface modification. , …”
Section: Introductionmentioning
confidence: 99%
“…To overcome this drawback, encapsulated micro-nanobubbles which consist of a gas core and an external membrane shell were adequately studied in previous works. In particular, three kinds of materials (i.e., proteins, lipids, and polymers , ) usually act as the membrane shell materials to stabilize the MNBs and provide them biocompatibility and echogenicity. Among the materials, lipids are the most widely used due to their safety, high stability, good biocompatibility, and ease of chemical surface modification. , …”
Section: Introductionmentioning
confidence: 99%