2021
DOI: 10.1002/exp.20210002
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Abstract: Biological applications of nanomaterials as delivery carriers have been embedded in traditional biomedical research for decades. Despite lagging behind, recent significant breakthroughs in the use of nanocarriers as tools for plant biotechnology have created great interest. In this Perspective, we review the outstanding recent works in nanocarrier‐mediated plant transformation and its agricultural applications. We analyze the chemical and physical properties of nanocarriers determining their uptake efficiency … Show more

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Cited by 21 publications
(15 citation statements)
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References 96 publications
(155 reference statements)
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“…In addition, normalization of TME may in turn improve tumor therapy outcome [ 4 ]. Thereby a large number of TME-responsive cancer treatment strategies have been developed in recent years [ 8 10 ], including chemodynamic therapy (CDT) [ 11 13 ] and hypoxic-sensitive chemotherapy [ 14 , 15 ].…”
Section: Introductionmentioning
confidence: 99%
“…In addition, normalization of TME may in turn improve tumor therapy outcome [ 4 ]. Thereby a large number of TME-responsive cancer treatment strategies have been developed in recent years [ 8 10 ], including chemodynamic therapy (CDT) [ 11 13 ] and hypoxic-sensitive chemotherapy [ 14 , 15 ].…”
Section: Introductionmentioning
confidence: 99%
“…The internalization mechanism of complexes is via endocytosis pathways in animal cells ( Midoux et al, 2008 ). But, the specific internalization mechanism of exogenous complexes remains unknown in plant cells ( Xia et al, 2021 ). The endocytotic pathway in plant cells is different from that in the animal; during the process, the pH of the endosomes does not decrease to a dangerous level.…”
Section: Resultsmentioning
confidence: 99%
“…Moreover, various nanoscale vectors, including lipid-based vectors, polymer-based nanocarriers, gold nanoparticles, inorganic nanoparticles, and self-assembled nucleic acid nanostructure, have been developed for efficient and safe therapeutic nucleic acid delivery to address the limitations of natural nucleic acids such as poor biological stability, limited cellular uptake, and unexpected tissue accumulation [ 7 , 42 , 43 , 44 ]. For example, Mirkin and coworkers reported the preparation of gold nanoparticle (AuNP)-ON conjugates and their use in intracellular gene regulation [ 45 ].…”
Section: Native Nucleic Acidsmentioning
confidence: 99%