From mesenchymal stem cells to their secretoms as basic components of dermal coverings for the treatment of massive burns

Abstract

In the course of our long term research, we have created new biotechnological productsdermal coverings (dermis equivalents) with the inclusion of human MSCs or their secretomes (cells conditioned mediums which contain a complex of biologically active substances synthesized by them). Preclinical studies on the model animals and clinical trials of new dermal equivalents on the limited group of patients with massive burns have been conducted to determine their therapeutic effectiveness and well as safety. We proved at special in vivo experiments that new dermal coverings contribute positively to the healing severe deep burn wounds when applied to the wound surface and don't reveal any toxic effect in the studied organisms. The developed method of obtaining new biotechnological products has been patented.K e y w o r d s: cellular biotechnology, dermal covering or dermis equivalent, mesenchymal stem cell (MSC), conditioned media (CM), secretome, burns.