1996
DOI: 10.1001/archderm.132.8.889
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From bedside to the bench and back. Nitric oxide and the cutis

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“…The production of large amounts of NO related to the increased activity of iNOS leads to self-destruction of melanocytes [ 18 ]. De novo attachment of melanocytes to the extracellular matrix is consequently reduced [ 46 ] and skin depigmentation is promoted [ 47 ].…”
Section: Discussionmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…The production of large amounts of NO related to the increased activity of iNOS leads to self-destruction of melanocytes [ 18 ]. De novo attachment of melanocytes to the extracellular matrix is consequently reduced [ 46 ] and skin depigmentation is promoted [ 47 ].…”
Section: Discussionmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Carbazole treatment caused a reduction in IL-15 synthesis by mononuclear lymphocytes, as well as decreased activation of NKlike T cells, yet had little effect on lymphocyte viability. We then examined production of iNOS, which has been found to be activated in psoriasis, and serves as a potential target of antipsoriatic therapy (Qureshi et al, 1996;Ormerod et al, 1998). Carbazole treatment led to modest decreases in iNOS activity and protein levels.…”
Section: Discussionmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“……”
Section: Conditions That May Be Due To Excess Nitric Oxide and Whymentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.