From bedside to the bench and back. Nitric oxide and the cutis

Qureshi, A. A.

doi:10.1001/archderm.132.8.889

Cited by 10 publications

(8 citation statements)

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“…The production of large amounts of NO related to the increased activity of iNOS leads to self-destruction of melanocytes [ 18 ]. De novo attachment of melanocytes to the extracellular matrix is consequently reduced [ 46 ] and skin depigmentation is promoted [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

“…NO is a highly reactive free radical with a short half-life, involved in several biological processes such as vascular homeostasis, neurotransmission, immunomodulation, and inflammation [ 16 , 17 ]. Although the well-known involvement in several physiological and pathophysiological conditions, its role in human melanogenesis is still under investigation [ 18 , 19 , 20 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

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Differential Expression of Nitric Oxide Synthase Isoforms nNOS and iNOS in Patients with Non-Segmental Generalized Vitiligo

Vaccaro

Irrera

Cutroneo

et al. 2017

IJMS

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Nitric oxide (NO) is involved in several biological processes, but its role in human melanogenesis is still not well understood. Exposure to UVA and UVB induces nitric oxide production in keratinocytes and melanocytes through the activation of constitutive nitric oxide synthase, increasing tyrosinase activity and melanin synthesis, whereas inducible nitric oxide synthase over expression might be involved in hypopigmentary disorders. The aim of this study was to evaluate whether inducible nitric oxide synthase and neuronal nitric oxide synthase expression were modified in vitiligo skin compared to healthy controls. Skin biopsies were obtained from inflammatory/lesional and white/lesional skin in 12 patients with active, non-segmental vitiligo; site-matched biopsies of normal skin from eight patients were used as controls. Nitric oxide synthase isoforms expression was evaluated by confocal laser scanning microscopy and Western Blot analysis. Inducible nitric oxide synthase expression was significantly increased in inflammatory/lesional skin compared to healthy skin; melanocytes showed a moderate neuronal nitric oxide synthase expression in white/lesional skin, demonstrating that metabolic function still goes on. The obtained data demonstrated that vitiligo lesions were characterized by modifications of nitric oxide synthase isoforms, thus confirming the hypothesis that nitric oxide imbalance is involved in vitiligo and supporting the idea that nitric oxide synthase inhibitors might be used as a possible therapeutic approach for the management of vitiligo.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Differential Expression of Nitric Oxide Synthase Isoforms nNOS and iNOS in Patients with Non-Segmental Generalized Vitiligo

Vaccaro

Irrera

Cutroneo

et al. 2017

IJMS

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“…Nitric oxide is present in various types of skin cells, including keratinocytes, melanocytes, Langerhans cells, fibroblasts and endothelial cells. Increased nitric oxide production is demonstrated in psoriasis, atopic dermatitis, irritant dermatitis, allergic dermatitis, lupus erythematous, sunburn-induced flushing, nerve-mediated flushing and skin swelling [ 7 , 8 ]. Given the role of nitric oxide as an endothelium-derived vasodilator, nitric oxide could be a culprit for causing the redness and inflammation of rosacea [ 8 ].…”

Section: Conditions That May Be Due To Excess Nitric Oxide and Whymentioning

confidence: 99%

Nitric Oxide Inhibition Strategies

Wong

Lerner

2015

Future Sci. OA

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“…Bunlar› destekler flekilde Qureshi ve ark. vitiligolu bir hastada demir eksikli¤i anemisinin tedavisinden sonra h›z-l› bir repigmentasyon geliflti¤ini bildirmifllerdir 6 . Öte yandan demir, hidrojen peroksidin hücre membranlar›-na, protein ve DNA'ya hasar veren serbest radikal iyonlar›na dönüflümünde katalizör olarak etki göstererek doku hasar›-na yol açabilir.…”

Section: Tart›flmaunclassified

“…Farelerle yap›lan bir deneysel çal›flmada karaci¤erde ferritin yap›m›n›n oksidatif stresle uyar›ld›¤› gösterilmifltir 10 . Bugüne dek vitiligoda antioksidanlar›n rolleri konusunda yap›-lan çal›flmalar esas olarak selenyum, katalaz, süperoksit dismutaz, glutatyon, glutatyon peroksidaz, malondialdehit, ksantin oksidaz ve NO'in serum ve/veya doku düzeyleri üzerine odaklanm›flt›r 5,6 . Bu çal›flmalar aras›nda baz› tutars›zl›klar bulunmakla birlikte, genel olarak oksidan ve antioksidan sistemler aras›nda bir dengesizlik bulunmas›n›n vitiligo patogenezinde rol oynayabilece¤i sonucuna var›lm›flt›r.…”

Section: Tart›flmaunclassified

Serum Iron and Ferritin Levels in Patients with Vitiligo

Mansur¹,

Aydıngöz²,

Göktay³

et al. 2010

turkderm

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ÖzetAmaç: Son y›llarda vitiligoda oksidatif stresin rolü konusunda çok say›da araflt›rma yap›lmaktad›r. Demir ve ferritin inflamasyon ve oksidatif reaksiyonlarda önemli rollere sahiptir, ancak bugüne dek vitiligolu hastalardaki demir metabolizmas› konusunda çok az yay›n bulunmaktad›r. Bu çal›flmada lokalize ve jeneralize vitiligolu hastalar›n serum demir ve ferritin düzeylerinin bir kontrol gurubuyla karfl›laflt›rmal› olarak de¤erlendirilmesi amaçlanm›flt›r. Gereç ve Yöntem: Çal›flma guruplar› son 1 ayd›r sistemik tedavi veya fototerapi uygulanmayan vitiligolu 68 hasta ve yafl/cins uyumlu, tinea pedis, nevus ve keratozlar gibi vitiligo d›fl› deri hastal›¤› olan 72 kontrol bireyinden oluflmaktayd›. Her hasta ve kontrol bireyinden sözlü onay al›nd›ktan sonra kahvalt› öncesinde kan örnekleri al›nd›. Bulgular: Vitiligolu hastalarla kontrol bireyleri aras›nda serum demir ve ferritin düzeyleri aras›nda anlaml› farkl›l›k bulunamad› (p=0,478, p=0,307). Bu parametreler lokalize ve jeneralize vitiligolu hastalar aras›nda farkl›l›k göstermedi (p=0,054, p=0,867). Ayr›ca, serum demir ve ferritin düzeyleri ile hastal›k süreleri aras›nda anlaml› bir ba¤›nt› görülmedi (p=0,382, p=0,485). Sonuç: Sonuçlar›m›z serum demir ve ferritin düzeylerinin vitiligo ve kontrol bireyleri aras›nda benzer oldu¤unu göstermek-tedir. Demir ve ferritinin doku düzeylerinin belirlenece¤i yeni araflt›rmalar bu moleküllerin vitiligodaki olas› rollerine ›fl›k tutabilir. (Türkderm 2010; 44: 153-5) Anahtar Kelimeler: Demir, ferritin, hematolojik parametreler, oksidatif stres, vitiligo SummaryBackground and Design: In recent years, the role of oxidative stress in vitiligo has been widely investigated. Iron and ferritin have important roles in inflammation and oxidative reactions. However, up to date, there are very limited studies on iron metabolism in patients with vitiligo. In this study, we aimed to investigate serum iron and ferritin levels in patients with localized and generalized vitiligo in comparison with a control group. Material and Method: The study groups comprised 68 patients with vitiligo who did not receive systemic treatment or phototherapy in the preceding month, and 72 age-and sex-matched patients with skin disorders other than vitiligo including tinea pedis, melanocytic nevi, and keratoses. Blood samples for serum iron and ferritin levels were obtained before breakfast, after verbal informed consent. Results: No statistically significant differences were found between vitilligo patients and control population with regard to serum levels of iron and ferritin (p=0.478, p=0.307). Patients with localized and generalized vitiligo were also similar for these parameters (p=0.054, p=0.867). Moreover, serum levels of iron and ferritin did not show any significant correlation with disease duration (p=0.382, p=0.485). Conclusion: Our results showed that serum iron and ferritin levels were similar in patients with vitiligo and control subjects. Further studies determining the skin levels of iron and ferritin may elucidate the probable role of the...

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From bedside to the bench and back. Nitric oxide and the cutis

Cited by 10 publications

References 0 publications

Differential Expression of Nitric Oxide Synthase Isoforms nNOS and iNOS in Patients with Non-Segmental Generalized Vitiligo

Differential Expression of Nitric Oxide Synthase Isoforms nNOS and iNOS in Patients with Non-Segmental Generalized Vitiligo

Nitric Oxide Inhibition Strategies

Serum Iron and Ferritin Levels in Patients with Vitiligo

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