1996
From bedside to the bench and back. Nitric oxide and the cutis
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“…The production of large amounts of NO related to the increased activity of iNOS leads to self-destruction of melanocytes [ 18 ]. De novo attachment of melanocytes to the extracellular matrix is consequently reduced [ 46 ] and skin depigmentation is promoted [ 47 ].…”
Section: Discussionmentioning
confidence: 99%
“…The production of large amounts of NO related to the increased activity of iNOS leads to self-destruction of melanocytes [ 18 ]. De novo attachment of melanocytes to the extracellular matrix is consequently reduced [ 46 ] and skin depigmentation is promoted [ 47 ].…”
Section: Discussionmentioning
confidence: 99%
“…Carbazole treatment caused a reduction in IL-15 synthesis by mononuclear lymphocytes, as well as decreased activation of NKlike T cells, yet had little effect on lymphocyte viability. We then examined production of iNOS, which has been found to be activated in psoriasis, and serves as a potential target of antipsoriatic therapy (Qureshi et al, 1996;Ormerod et al, 1998). Carbazole treatment led to modest decreases in iNOS activity and protein levels.…”
Section: Discussionmentioning
confidence: 99%
“……”
Section: Conditions That May Be Due To Excess Nitric Oxide and Whymentioning
confidence: 99%
