Friend or foe: RIG- I like receptors and diseases

Liu, Longding; Li, Muyuan; Li, Caiyan; Liu, Ke; Zhu, Yaxi; Zhang, Huali

doi:10.1016/j.autrev.2022.103161

Cited by 16 publications

(11 citation statements)

References 218 publications

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“…RIG-I/MDA5 is a pattern recognition receptor (PRR) localized in the cytoplasm that recognizes double-stranded RNA (dsRNA) production and induces IFN synthesis in a TLR-independent manner. Excessive activation of the RIG-I signaling pathway leads to the upregulation of type I IFN expression ( Song et al., 2022 ). Many viruses encode specific proteins that inhibit RIG-I-mediated expression of IFNs and thus evade elimination by the host immune system ( Talon et al., 2000 ; Hayman et al., 2006 ).…”

Section: Discussionmentioning

confidence: 99%

HIF-1α promotes virus replication and cytokine storm in H1N1 virus-induced severe pneumonia through cellular metabolic reprogramming

Meng,

Zhu,

Yang

et al. 2024

Virologica Sinica

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Section: Discussionmentioning

confidence: 99%

HIF-1α promotes virus replication and cytokine storm in H1N1 virus-induced severe pneumonia through cellular metabolic reprogramming

Meng,

Zhu,

Yang

et al. 2024

Virologica Sinica

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“…RLRs encompass three homologous members, including RIG-I (or DEAD box polypeptide 58, DDX58), melanoma differentiation-associated gene 5 (MDA5), and laboratory of genetics and physiology 2 (LGP2) ( 33 ). During SARS-CoV-2 infection, RIG-1 and MDA5 are mainly involved in identifying viral RNA and inhibiting viral replication by recognizing viral intermediate dsRNA.…”

Section: Innate Immune Systemmentioning

confidence: 99%

Innate and adaptive immunity to SARS-CoV-2 and predisposing factors

et al. 2023

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The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2), has affected all countries worldwide. Although some symptoms are relatively mild, others are still associated with severe and even fatal clinical outcomes. Innate and adaptive immunity are important for the control of SARS-CoV-2 infections, whereas a comprehensive characterization of the innate and adaptive immune response to COVID-19 is still lacking and the mechanisms underlying immune pathogenesis and host predisposing factors are still a matter of scientific debate. Here, the specific functions and kinetics of innate and adaptive immunity involved in SARS-CoV-2 recognition and resultant pathogenesis are discussed, as well as their immune memory for vaccinations, viral-mediated immune evasion, and the current and future immunotherapeutic agents. We also highlight host factors that contribute to infection, which may deepen the understanding of viral pathogenesis and help identify targeted therapies that attenuate severe disease and infection.

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“…Retinoic-acid-inducible gene I (RIG-I)-like receptors (RLRs) are a family of DExD/H box RNA helicases that function as cytoplasmic sensors of PAMPs within viral RNA and thus can detect a broad range of viruses. They could mediate the transcriptional induction of genes encoding type I IFNs and proinflammatory cytokines that elicit an intracellular immune response to control virus infection [ 62 , 63 ]. RLRs encompass three members: RIG-I, melanoma differentiation-associated protein 5 (MDA5), and laboratory of genetics and physiology 2 (LGP2) [ 64 ].…”

Section: Sars-cov-2 and Rlrsmentioning

confidence: 99%

Cellular Sensors and Viral Countermeasures: A Molecular Arms Race between Host and SARS-CoV-2

Sun

Chan

Yuan

2023

Viruses

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the coronavirus disease 2019 (COVID-19) pandemic that has caused disastrous effects on the society and human health globally. SARS-CoV-2 is a sarbecovirus in the Coronaviridae family with a positive-sense single-stranded RNA genome. It mainly replicates in the cytoplasm and viral components including RNAs and proteins can be sensed by pattern recognition receptors including toll-like receptors (TLRs), RIG-I-like receptors (RLRs), and NOD-like receptors (NLRs) that regulate the host innate and adaptive immune responses. On the other hand, the SARS-CoV-2 genome encodes multiple proteins that can antagonize the host immune response to facilitate viral replication. In this review, we discuss the current knowledge on host sensors and viral countermeasures against host innate immune response to provide insights on virus–host interactions and novel approaches to modulate host inflammation and antiviral responses.

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Friend or foe: RIG- I like receptors and diseases

Cited by 16 publications

References 218 publications

HIF-1α promotes virus replication and cytokine storm in H1N1 virus-induced severe pneumonia through cellular metabolic reprogramming

HIF-1α promotes virus replication and cytokine storm in H1N1 virus-induced severe pneumonia through cellular metabolic reprogramming

Innate and adaptive immunity to SARS-CoV-2 and predisposing factors

Cellular Sensors and Viral Countermeasures: A Molecular Arms Race between Host and SARS-CoV-2

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