Frequency-Specific Local Synchronization Changes in Paroxysmal Kinesigenic Dyskinesia

Liu, Zhirong; Miao, Huan-Huan; Yu, Yang; Ding, Meiping; Liao, Wei

doi:10.1097/md.0000000000003293

Cited by 9 publications

(12 citation statements)

References 42 publications

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“…Conversely, decreased E glob and increased L p were also found in the PKD-M group, indicating a PRRT2 mutationrelated impact on human neurophysiology. Loss-of-function mutations in PRRT2 could lead to synaptic dysfunction; our observation is in accordance with the results of a magnetoencephalographic study which showed that PRRT2-related PKD patients had greater reduction in peak gamma frequency than non-PRRT PKD patients (Z. R. Liu, Miao, Yu, Ding, & Liao, 2016). Consistent with this, the PRRT2 knockout mouse shows impaired functional stability of neuronal networks resulting from short-term plasticity changes, rendering it more susceptible to paroxysmal events triggered by external stimuli (Michetti et al, 2017).…”

Section: Global Topological Alterations In Pkd-m and Pkd-n Patientssupporting

confidence: 91%

Brain structural connectome in relation to PRRT2 mutations in paroxysmal kinesigenic dyskinesia

Lei

Suo

et al. 2020

Human Brain Mapping

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This study explored the topological characteristics of brain white matter structural networks in patients with Paroxysmal Kinesigenic Dyskinesia (PKD), and the potential influence of the brain network stability gene PRRT2 on the structural connectome in PKD. Thirty‐five PKD patients with PRRT2 mutations (PKD‐M), 43 PKD patients without PRRT2 mutations (PKD‐N), and 40 demographically‐matched healthy control (HC) subjects underwent diffusion tensor imaging. Graph theory and network‐based statistic (NBS) approaches were performed; the topological properties of the white matter structural connectome were compared across the groups, and their relationships with the clinical variables were assessed. Both disease groups PKD‐M and PKD‐N showed lower local efficiency (implying decreased segregation ability) compared to the HC group; PKD‐M had longer characteristic path length and lower global efficiency (implying decreased integration ability) compared to PKD‐N and HC, independently of the potential effects of medication. Both PKD‐M and PKD‐N had decreased nodal characteristics in the left thalamus and left inferior frontal gyrus, the alterations being more pronounced in PKD‐M patients, who also showed abnormalities in the left fusiform and bilateral middle temporal gyrus. In the connectivity characteristics assessed by NBS, the alterations were more pronounced in the PKD‐M group versus HC than in PKD‐N versus HC. As well as the white matter alterations in the basal ganglia‐thalamo‐cortical circuit related to PKD with or without PRRT2 mutations, findings in the PKD‐M group of weaker small‐worldness and more pronounced regional disturbance show the adverse effects of PRRT2 gene mutations on brain structural connectome.

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Section: Global Topological Alterations In Pkd-m and Pkd-n Patientssupporting

confidence: 91%

Brain structural connectome in relation to PRRT2 mutations in paroxysmal kinesigenic dyskinesia

Lei

Suo

et al. 2020

Human Brain Mapping

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“…To the best of our knowledge, this is the first study to examine abnormalities of regional synchronization in a relatively large and typical pediatric TS population using the frequency specificity of ReHo. Several studies demonstrated the frequency specificity of ReHo changes in neurologic and psychiatric disorders, such as paroxysmal kinesigenic dyskinesia (42), schizophrenia (43), and major depression (44). In the present study, significantly increased ReHoin the superior frontal gyrus and superior parietal gyrus of TS children indicated compensatory functions of the frontal-parietal network in the lower frequency bands.…”

Section: Frequency-specific Altered Synchronization In Tssupporting

confidence: 68%

Frequency-Specific Regional Homogeneity Alterations in Tourette Syndrome

Lou

Wang

et al. 2020

Front. Psychiatry

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Tourette syndrome (TS) is a developmental neuropsychiatric disorder with onset during childhood. Because of its complex spectrum of phenotypes, the underlying pathophysiology of TS is still unclear. Resting-state functional magnetic resonance imaging demonstrated aberrant spontaneous neural synchronization in conventional frequency band (0.01–0.08 Hz) in TS. No published studies have reported abnormalities of local synchronization across different frequency bands. We estimated the alterations of local synchronization across five bands ranging from 0 to 0.25 Hz. Seventy-nine children with TS and 63 age-, sex-, and handedness-matched healthy children were recruited. Frequency-specific regional homogeneity (ReHo) and independent component analysis were used to identify functional alterations between TS and healthy children. TS patients showed significantly increased ReHo in the left precentral gyrus and decreased ReHo in the right operculum. Abnormal ReHo alterations of the superior frontal gyrus, superior parietal gyrus, anterior cingulate gyrus, putamen, superior temporal gyrus, and operculum were observed in different frequency bands. TS patients showed increased connectivity of the right superior frontal gyrus within the left executive control network. In addition, a significantly negative correlation was found between Yale Global Tic Severity Scale (YGTSS) vocal score and ReHo values of the right operculum in the highest frequency bands (0.198–0.25 Hz), while a significant positive correlation was found between YGTSS motor score and altered connectivity of the right superior frontal gyrus. The present study revealed frequency-specific abnormal alterations of ReHo in the whole brain and altered connectivity within the executive control network of TS children. Its neural importance and clinical practicability require further investigation.

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“…The exact biological meaning of ReHo measurements in different frequency bands still needs to be further explored. Several studies demonstrated the frequency dependence of the ReHo changes in different neurological conditions (49-52). Future rs-fMRI research focusing on the biological meaning of ReHo should be conducted in both healthy subjects and patients with specific conditions using spectrum-specific analytical strategies.…”

Section: Analytic Methodsmentioning

confidence: 99%

Resting-State Functional MRI: Everything That Nonexperts Have Always Wanted to Know

Wang

Tong

et al. 2018

AJNR Am J Neuroradiol

295

319

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SUMMARY:Resting-state fMRI was first described by Biswal et al in 1995 and has since then been widely used in both healthy subjects and patients with various neurologic, neurosurgical, and psychiatric disorders. As opposed to paradigm-or task-based functional MR imaging, resting-state fMRI does not require subjects to perform any specific task. The low-frequency oscillations of the resting-state fMRI signal have been shown to relate to the spontaneous neural activity. There are many ways to analyze resting-state fMRI data. In this review article, we will briefly describe a few of these and highlight the advantages and limitations of each. This description is to facilitate the adoption and use of resting-state fMRI in the clinical setting, helping neuroradiologists become familiar with these techniques and applying them for the care of patients with neurologic and psychiatric diseases.ABBREVIATIONS: ALFF ϭ Amplitude of Low Frequency Fluctuations; BOLD ϭ blood oxygen level-dependent; FCD ϭ functional connectivity density; ICA ϭ

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Frequency-Specific Local Synchronization Changes in Paroxysmal Kinesigenic Dyskinesia

Cited by 9 publications

References 42 publications

Brain structural connectome in relation to PRRT2 mutations in paroxysmal kinesigenic dyskinesia

Brain structural connectome in relation to PRRT2 mutations in paroxysmal kinesigenic dyskinesia

Frequency-Specific Regional Homogeneity Alterations in Tourette Syndrome

Resting-State Functional MRI: Everything That Nonexperts Have Always Wanted to Know

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