Frequency of twelve carcinogenic human papilloma virus types among women from the South Backa region, Vojvodina, Serbia

Kovačević, Gordana; Nikolić, Nataša; Jovanovic-Galovic, A.; Hrnjakovic-Cvjetkovic, Ivana; Vuleta, Dinko; Patić, Aleksandra; Radovanov, Jelena; Milosević,

doi:10.3906/sag-1410-47

Cited by 6 publications

(3 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the female population from Kosovo, the crude overall prevalence of infection with any of the 14 HR-HPVs was estimated at 13.1%. Interestingly, in our study population the overall HR-HPV prevalence in NILM was lower than in studies on a total of 10.744 eligible women from other countries in central and eastern Europe (9.7%; 95% CI: 6.1-15.2% vs. 18.0%; 95% CI: 17.0-19.0%, respectively) [15][16][17][18][19][20][21][22][23], with reported high incidence rates of cervical cancer and related mortality rates [1]. Our results were concordant with those obtained in the largest study in the region to date, performed on 4.199 Slovenian women (HR-HPV prevalence of 10.7%; cervical cancer incidence rate per 100,000: 13.4; mortality rate due to cervical cancer per 100,000: 6.1) [1,14], as well as with global data (HR-HPV prevalence of 10.4%; cervical cancer incidence rate per 100,000: 15.1; mortality rate due to cervical cancer per 100,000: 7.6) [1,5].…”

Section: Discussioncontrasting

confidence: 80%

Pre-vaccination prevalence of high-risk human papillomaviruses (HPV) in women from Kosovo and their related sociodemographic characteristics

et al. 2018

View full text Add to dashboard Cite

Objectives: Kosovo's current health care system does not support organized nationwide cervical cancer screening and human papillomavirus (HPV) vaccination programs. To date, no reliable data are available on cervical cancer incidence and mortality in Kosovo, or on high-risk HPV (HR-HPV) prevalence and HPV type distribution. Our aim is to determinate the pre-vaccination prevalence and distribution of HR-HPVs and to assesses the associations between sociodemographic characteristics and increased risk of HPV infection in women from Kosovo. Material and methods: Detection of HR-HPV DNA in cytologically evaluated cervical smears was performed using a clinically validated Abbott RealTime High Risk HPV test, Roche Linear Array HPV Genotyping Test, HPV52 type-specific real-time PCR and an in-house GP5+/GP6+/68 PCR. Results: The crude overall prevalence of any of the HR-HPVs was estimated at 13.1% (26/199; 95% confidence interval (CI): 9.1-18.5%), with HPV16 being the most common type (7/26, 26.9%), followed by HPV31 and HPV51, each detected in 4/26 (15.4%) cervical specimens, HPV18, detected in 3/26 (11.5%) specimens, HPV52 and HPV66, each detected in 2/26 (7.7%) specimens, and HPV33, HPV45, HPV56, and HPV58, each detected in a single (3.9%) specimen. Women over 40 (OR = 0.36), older than 18 at sexual debut (odds ratio (OR) = 0.28), those that had delivered at least one child (OR = 0.32), and those that had a history of pregnancy termination (OR = 0.39) were at lower risk for HPV infection. Conclusion: Because more than 70% of cervical precancerous lesions could have been prevented in Kosovo using nationwide HPV-based cervical cancer screening and HPV vaccination, it is of outmost importance to implement both programs in the national health care system as soon as possible.

show abstract

Section: Discussioncontrasting

confidence: 80%

Pre-vaccination prevalence of high-risk human papillomaviruses (HPV) in women from Kosovo and their related sociodemographic characteristics

et al. 2018

View full text Add to dashboard Cite

show abstract

“…There was a significant difference in the prevalence of total HR HPV infections across the various age groups (χ 2 test, χ 2 = 264.415, p < 0.001) ( Supplementary Materials Table S1 ). More precisely, the first peak was recorded under the age of 31 years, which was in line with the previous study [ 44 ]; then, it decreased slightly and maintained a plateau in the middle-age group of women (31–60 years), followed by a second peak in the group after 61 years ( Figure 4 ). Age at first sexual activity corresponds with the first peak [ 4 ].…”

Section: Discussionsupporting

confidence: 91%

Prevalence of Carcinogenic Genotypes of HPV-Infected Women in a Ten-Year Period (2014–2023) in Vojvodina, Serbia

Nikolic,

Basica,

Strbac

et al. 2024

Medicina

Self Cite

View full text Add to dashboard Cite

Background and Objectives: Human papillomavirus (HPV) infection and its etiological role in the development of cervical cancer are well established. The cervical cancer mortality rate in Serbia is one of the highest among European countries, and this cancer is the second-leading cause of death in Serbian women aged from 15 to 44. Materials and Methods: This retrospective study was conducted at the Institute of Public Health of Vojvodina. A total of 10,062 cervical specimens from Serbian women were collected and HPV tested in ten years. The study patients were divided into five age groups. HPV genotype testing was performed using a commercial kit to detect 14 high-risk (HR) HPV genotypes. Additionally, cervix cytology data have been available for patients tested in 2022 and 2023. Results: An overall positive rate was found in 43.3% of patients (4356/10,062). A single HPV infection (62.1%) was the main infection pattern. The most frequent HR HPV genotypes were HPV 16, 31, 52, 56, 39, and 51, comprising 62.3% of the detected genotypes, including multiple infections. A significant difference was noted in the HPV prevalence across the different age groups, with a bimodal distribution of HPV infection. The highest prevalence was recorded in the age group ≤ 30 and those after 61 years. Women diagnosed with high-grade squamous intraepithelial lesions (HSIL) were significantly older compared to others. HR HPV is the most prevalent in patients with HSIL cytological findings (76.5%). The most common type, according to age-specific distribution and cytological findings, was HR HPV 16. Conclusions: This study provides comprehensive data on HR HPV distribution among Serbian women, which can serve as a basis for subsequent monitoring of genotypic distribution. It is particularly significant considering they are missing in the updated ICO/IARC Report for Serbia, and the cervical cancer mortality rate in Serbia is one of the highest among European countries.

show abstract

“…We compared our data with these ones of other Balkan countries. In Macedonia the most common reported types are HPV16 (28.4%), HPV31 (12.1%) and HPV66 (7.9%) [Duvlis S et al, 2001]; in Greece -HPV16 (23.3%) followed by HPV53 (21.6%) [Stamataki P et al, 2010]; in Turkey -HPV16 (32%), HPV18 (8%) and HPV31 (6%) [Dursun P et al, 2013]; in Serbia -HPV16 (37.3%), HPV31 (31.7%) and HPV51 (15.5%) [Kovacevic G et al, 2016]; in Romania -HPV16 (28.1%), HPV53 (14.5%) and HPV51 (13.5%) [Ursu RG et al, 2011]. Obviously, the high incidence of medium-risk HPV66 is characteristic mainly for Bulgarian and Macedonian patients, but it is not observed in other Balkan countries.…”

Section: Discussionmentioning

confidence: 99%

Molecular-Epidemiological Study for 19 High and Medium-Risk HPV types in Bulgarian Patients

Hristova-Savova¹,

Asen²,

Dimova³

2019

ijSciences

View full text Add to dashboard Cite

Cervical cancer ranks as the 4 th leading cause of female cancer and cancer deaths in the world. More than 99% of cervical cancer cases are due to HPV infection. Vaccination can significantly reduce the number of HPVrelated cancers in the future. The next big step is to change the order of the tests, ie. cervical cells are first tested for HPV, and then analyzed under a microscope. The objective of our study was to define the incidence of 19 types of HPV in Bulgarian women attended for routine gynecologic examination, in order to obtain the molecularepidemiological spectrum of this infection in the context of the actual preventive programs. We have used the medium-high risk PapillomaStrip kit, based on the principle of reverse hybridization, in samples of 151 Bulgarian women. We detected the total frequency of 44.4% for HPV infection and higher frequency in younger age group (<30 years-47.5% and 30-40 years-50%) compared to > 40 years old women (28%). The most frequent HPV types from our study were HPV 45 and 52 (10.6%), HPV 66 (8.6%) and HPV 31 (8%). In PAPI/II it was HPV52 (11.3%), followed by HPV45 (10.5%) and HPV66 (8.3%). In PAPIII the most common was HPV16 (44.4%), followed by HPV 45, 31, 66 and 59 (each of 22.2%). We emphasized on the high frequency of HPV45 in our study, which is reported as one of the most frequent types in cervical cancer. In conclusion, HPV genotyping provides information on the carriage of high-risk types and increased attention to these patients. This is a valuable information for planning preventive programs in regard to choosing diagnostic tests and vaccination. Our results revealed the wide spectrum of HPV infection in Bulgarian women, as about 70% of infected patients carry high-risk HPV 45, 52, 31, 16 and 18.

show abstract

Frequency of twelve carcinogenic human papilloma virus types among women from the South Backa region, Vojvodina, Serbia

Cited by 6 publications

References 34 publications

Pre-vaccination prevalence of high-risk human papillomaviruses (HPV) in women from Kosovo and their related sociodemographic characteristics

Pre-vaccination prevalence of high-risk human papillomaviruses (HPV) in women from Kosovo and their related sociodemographic characteristics

Prevalence of Carcinogenic Genotypes of HPV-Infected Women in a Ten-Year Period (2014–2023) in Vojvodina, Serbia

Molecular-Epidemiological Study for 19 High and Medium-Risk HPV types in Bulgarian Patients

Contact Info

Product

Resources

About