2020
DOI: 10.1515/jpem-2020-0032
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Abstract: BackgroundThe thyroid gland of patients with congenital heart disease may be exposed to large doses of iodine from various sources. We assessed the thyroid response after iodine exposure during conventional angiography in cardiac catheterization and angiographic computer tomography in childhood.MethodsRetrospective mid- to long-term follow-up of 104 individuals (24% neonates, 51% infants, 25% children) with a median age and body weight of 104 days [0–8 years] and 5.3 kg [1.6–20]. Serum levels of thyroid-stimul… Show more

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Cited by 8 publications
(5 citation statements)
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“…However, seven out of these twelve patients had transient thyroid hypofunction. This nding is consistent with previous reports of thyroid dysfunction following CC [2,4,7,8]. In a retrospective study conducted on 104 children with CHD (aged from 0-8 years), post-cardiac catheter hypothyroidism was reported in 15.4% of the studied population and it was transient in 14 out of 16 patients [4].…”
Section: Discussionsupporting
confidence: 92%
See 2 more Smart Citations
“…However, seven out of these twelve patients had transient thyroid hypofunction. This nding is consistent with previous reports of thyroid dysfunction following CC [2,4,7,8]. In a retrospective study conducted on 104 children with CHD (aged from 0-8 years), post-cardiac catheter hypothyroidism was reported in 15.4% of the studied population and it was transient in 14 out of 16 patients [4].…”
Section: Discussionsupporting
confidence: 92%
“…Infants with congenital heart diseases (CHD) are more prone to hypothyroidism due to higher frequency of abnormal thyroid morphology and routine exposure to supraphysiological doses of iodine [3]. The sources of excess iodine in those infants are either iodinated contrast media (iCM) during computed tomography angiography (CT-A) and cardiac catheterization (CC), or topical iodine containing antiseptics used for disinfection [2,4]. Furthermore, infants undergoing CC are exposed to variable doses of ionizing radiation which are usually higher during complex procedures [6].…”
Section: Introductionmentioning
confidence: 99%
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“…The main dietary sources of iodine are iodized salt, seafood, and dairy products ( 165 ). Seaweeds are rich in iodine but the iodine content of seaweeds and dairy products varies considerably ( 166 ). Sea salt, Himalayan salt, and salt used in food processing is not always rich in iodine ( 148 ).…”
Section: Effects Of Foods Drugs/diseases Supplementation and Nutritio...mentioning
confidence: 99%
“…The aetiology of hypothyroidism is multifactorial, but the most frequent causes are excess iodine intake and/or critical illness. Exposure to iodinated Contrast Media (iCM) is an increasingly common source of excess iodine in vulnerable patients ( 166 ). The thyroid gland has two auto-release mechanisms to manage high intra-thyroid iodine doses, namely the Via the Wolff–Chaikoff effect and the escape phenomenon ( 167 ).…”
Section: Effects Of Foods Drugs/diseases Supplementation and Nutritio...mentioning
confidence: 99%