“…Fatigue was the most frequently reported symptom, and pain, depression, and anxiety were the most distressing symptoms for patients with advanced cancer in various palliative care settings according to two analysis. 9,17 The frequency of these symptoms could be related to the cancer type (e.g., a patient with lung cancer may have dyspnea as his main symptom, whereas a patient with bone cancer may mainly complain of pain), the cancer stage (e.g., an asymptomatic patient newly diagnosed with prostate cancer (stage I) may complain of back pain when his disease becomes advanced), and the setting of care (e.g., a patient newly diagnosed with metastatic colon cancer could be asymptomatic and receiving chemotherapy in the outpatient setting and could be delirious in the palliative care unit). Further research is needed to determine the characteristics of the symptom burden for each cancer at any point in its course and in specific care settings.…”