Frequency of Lymphoceles after Open and Laparoscopic Pelvic Lymph Node Dissection in Patients with Prostate Cancer

Solberg, Arne; Angelsen, Anders; Bergan, Unni; Haugen, Øystein; Viset, Trond; Klepp, Olbjørn

doi:10.1080/00365590310008082

Cited by 110 publications

(92 citation statements)

References 13 publications

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“…15 Up to 64% of patients developed lymphoceles, which is the highest number reported in the literature. [13][14][15] To our surprise, significantly more patients developed lymphoceles after MI-PLND (71%) compared with O-PLND (47%). We have no clear explanation for this surprise finding, as one would expect the transperitoneal approach in the MI group to allow drainage of lymph fluid into the peritoneal cavity.…”

mentioning

confidence: 88%

“…With MI-PLND, 95 patients (95%) underwent extended and five patients (5%) underwent limited PLND: two obturator + hypogastric and three obturator-only. Operation time (skin-to-skin) was longer with MI-PLND (130 [70-240] vs 98 [59-200] min; P < 0.001), but there was less blood loss with MI-PLND (drop in hemoglobin on postoperative day 1: 1.1 ± 0.91 vs 1.7 ± 0.76 g/dL; P = 0.001) and hospital stay was shorter (3 [2][3][4][5][6][7][8][9][10][11][12][13][14] vs 6 [3-10] days; P < 0.001).…”

Section: Surgical Detailsmentioning

confidence: 99%

“…Contrary to the present findings, Solberg et al found fewer lymphoceles after laparoscopic PLND versus O-PLND (37% vs 61% respectively; P = 0.013). 13 This is possibly because in the former study, unlike O-PLND patients, men undergoing laparoscopic PLND did not receive prophylactic LMWH. Use of LMWH is associated with increased lymph leakage, and it is recommended to inject LMWH into the upper arm rather than the abdomen.…”

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confidence: 93%

“…[8][9][10][11][12] Overall, (asymptomatic) lymphoceles have been reported in 18-61% of patients. [13][14][15] To our knowledge, only one study prospectively assessed the complication rate after laparoscopic staging PLND using a standardized classification. 12 The goal of the present study was to assess complications of staging MI-PLND by reporting on surgical outcome and compare this with O-PLND.…”

Section: Introductionmentioning

confidence: 99%

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Contemporary minimally‐invasive extended pelvic lymph node dissection for prostate cancer before curative radiotherapy: Prospective standardized analysis of complications

et al. 2014

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Abbreviations & AcronymsObjectives: To prospectively assess contemporary complication rates of minimallyinvasive staging pelvic lymph node dissection before curative radiotherapy for prostate cancer using a standardized classification. Methods: A total of 100 prostate cancer patients underwent laparoscopic or robotassisted pelvic lymph node dissection (95% extended). Surgical outcomes were compared with those of 43 patients undergoing open pelvic lymph node dissection (33% extended).Complications were recorded prospectively during hospitalization and follow-up visits, and graded using Clavien-Dindo classification. Lymphocele size was measured on postoperative magnetic resonance imaging or computed tomography. Results: Of the complications recorded, 10% were grade 1, 3% were grade 2 and 6% were grade 3. No grade 4-5 complications occurred. Compared with open pelvic lymph node dissection, minimally-invasive pelvic lymph node dissection was associated with less blood loss (P = 0.001) and shorter hospital stay (median 3 vs 6 days; P < 0.001), but longer operation time (130 vs 98 min; P < 0.001). The complication rate was similar in both groups. For the entire cohort, overall and symptomatic lymphoceles were seen in 91 (64%) and 18 patients (13%), respectively. On multivariate logistic regression, minimally-invasive surgery was the only independent predictor for lymphocele development (odds ratio 3.99; P = 0.015). Conclusions: Minimally-invasive extended pelvic lymph node dissection before curative radiotherapy is associated with low morbidity. Asymptomatic lymphocele development rate is higher compared with open pelvic lymph node dissection.

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confidence: 88%

Section: Surgical Detailsmentioning

confidence: 99%

mentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

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Contemporary minimally‐invasive extended pelvic lymph node dissection for prostate cancer before curative radiotherapy: Prospective standardized analysis of complications

et al. 2014

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“…3 ) are common although their incidence is reportedly lower following robotassisted or laparoscopic surgery compared with open surgery (Solberg et al 2003 ). The majority of these are asymptomatic, found adjacent to surgical clips along the nodal dissection chain and will resolve spontaneously.…”

Section: Complications Following Surgerymentioning

confidence: 99%

Female Pelvis: Genital Organs

Forstner

Cunha²

2015

Imaging of Complications and Toxicity Following Tumor Therapy

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Medical Radiology-Diagnostic Imaging is a unique series that aims to document the most innovative technologies in all fi elds within diagnostic imaging and interventional radiology, thereby informing the physician in practice of the latest advances in diagnostic imaging and percutaneous imageguided minimally invasive procedures. Th e contents are intended to cover all organs, and all modern imaging techniques and image-guided treatment modalities, with special emphasis on applications in clinical practice. Each volume is a comprehensive reference book on a topical theme, and the editors are always experts of high international standing. Contributions are included from both clinicians and researchers, ensuring wide appeal. Medical Radiology -Radiation Oncology is a unique series that aims to document the most innovative technologies in all fi elds within radiology, thereby informing the physician in practice of the latest advances in diagnostic and treatment techniques. Th e contents range from contemporary statements relating to management for various disease sites to explanations of the newest techniques for tumor identifi cation and of mechanisms for the enhancement of radiation eff ects, with the emphasis on maximizing cure and minimizing complications. Each volume is a comprehensive reference book on a topical theme, and the editors are always experts of high international standing. Contributions are included from both clinicians and researchers, ensuring wide appeal. This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifi cally the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfi lms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specifi c statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. AbstractA precise knowledge of antineoplastic drugs is an indispensable basis for the care of patients with cancer. The mechanisms of action and resistance, cross-resistance patterns, pharmacodynamics and pharmacokinetics, pharmacological interaction, and last but not least potential adverse effects should be part of this knowledge. As contemporary cancer care requires interdisciplinary and multiprofessional structures, the radiologist is an important a...

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Imaging of Complications and Toxicity Following Tumour Therapy: Pelvis and Genitourinary (Male)

Shah

Sohaib

Koh

2015

Imaging of Complications and Toxicity Following Tumor Therapy

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Frequency of Lymphoceles after Open and Laparoscopic Pelvic Lymph Node Dissection in Patients with Prostate Cancer

Abstract: Although the overall frequency of lymphocele formation was high, clinically significant lymphoceles were scarce. LPLND was associated with a statistically significant lower frequency of lymphocele formation compared to OPLND.

Cited by 110 publications

References 13 publications

Contemporary minimally‐invasive extended pelvic lymph node dissection for prostate cancer before curative radiotherapy: Prospective standardized analysis of complications

Contemporary minimally‐invasive extended pelvic lymph node dissection for prostate cancer before curative radiotherapy: Prospective standardized analysis of complications

Female Pelvis: Genital Organs

Imaging of Complications and Toxicity Following Tumour Therapy: Pelvis and Genitourinary (Male)

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