Frequency of Hepatorenal Syndrome Among Patients With Cirrhosis and Outcome After Treatment

Abstract

Introduction Hepatorenal syndrome is the third most common cause of admissions among patients with liver cirrhosis and has a high mortality rate. It is a progressive deterioration of renal function in a patient with acute or chronic liver failure. The only definite curative treatment of choice for hepatorenal syndrome is liver transplantation. This study aimed to determine the frequency of hepatorenal syndrome among patients with liver cirrhosis and to determine its outcome after treatment. Patients and Methods This case series prospective study was conducted at the Department of Medicine, CMH Lahore Medical College and Institute of Dentistry, Pakistan, from January 2019 to December 2019. The study included 136 patients of cirrhosis who were identified and worked up for hepatorenal syndrome. The patients with liver cirrhosis diagnosed as having hepatorenal syndrome were given treatment comprising injection terlipressin 2 mg four times a day and injection Haemaccel twice a day for two weeks, and after that the outcome was measured with a follow-up of six weeks. Results A total of 136 patients of cirrhosis were included in the study. Of the patients, 14 (10.3%) were diagnosed as suffering from hepatorenal syndrome. These diagnosed cases were given treatment for two weeks. Three (21.4%) of the patients having hepatorenal syndrome did not show any response, two (14.3%) patients recovered partially, four (28.6%) patients recovered fully, and four (28.6%) expired within one month of the treatment. One (7.14%) patient was referred during the treatment for liver transplant. Conclusions Hepatorenal syndrome is a common complication of cirrhosis. The treatment of systemic vasoconstrictors for hepatorenal syndrome proved to be effective in our study and should be the first priority for treating hepatorenal syndrome especially in places like Pakistan where liver transplantation is not that easily available.

Real-World Utilization of Corticosteroids in Severe Alcoholic Hepatitis: Eligibility, Response, and Outcomes

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Frequency and Outcomes of Hepatorenal Syndrome in Patients with Chronic Liver Disease

“…Inayat Ullah et al [19] reported that the frequency of HRS among liver cirrhosis patients was 19.9%. Fida S et al [18] demonstrated that HRS was found in 10.3% patients who were diagnosed to have liver cirrhosis.…”

“…Duration of disease was 5.46±3.82 years in our study. A study conducted by Fida S et al [18] to evaluate the frequency of HRS among cirrhotic patients demonstrated that according to etiology 24.26% patients had hepatitis B, 30.88% patients had hepatitis C, 8.09% patients had hepatitis B and C both and remaining patients were having cirrhosis due to different etiology.…”

Apigenin enhances sorafenib anti-tumour efficacy in hepatocellular carcinoma

“…The ability of the combination-treated group to promote overall improvement in hepatic histoarchitecture underscores the therapeutic potential of the combined treatment. Prolonged liver cancer and other chronic liver injuries may lead to the development of hepatorenal syndrome characterized by renal dysfunction in patients with liver disease [33] . In the current study, the HCC model group showed notable abnormalities in the kidney, lung, and spleen.…”