Frequency of "Dementia of Unknown Etiology" Increases With Age

Neuropathology of Dementia Disorders

“…VaD showed a continuing age-related decrease from 15.6 to 9.4% (p<0.05), whereas AD + Lewy pathology remained fairly stable (10.3 and 11%). In a prospective study of 180 demented patients (mean age 85 ± 3.4 years), autopsy showed AD in 48%, AD with vascular pathology in 19%, VaD in 11%, DLB in 9%, and dementia of unknown etiology in 13% [270], confirming the notion that a high percentage of demented persons aged 80+ do not meet the pathological criteria of AD or were classified as "dementia of unknown etiology" [97,276,277]. A 90+ study revealed significantly less severe Aβ, αSyn and TP'D-43 pathologies and hippocampal lesions in non-demented subjects, while Aβ distribution showed no esssential differences; non-demented individuals had limited hippocampal tau and neocortical Aβ pathology [241].…”

Neuropathology of Dementia Disorders

“…VaD showed a continuing age-related decrease from 15.6 to 9.4% (p<0.05), whereas AD + Lewy pathology remained fairly stable (10.3 and 11%). In a prospective study of 180 demented patients (mean age 85 ± 3.4 years), autopsy showed AD in 48%, AD with vascular pathology in 19%, VaD in 11%, DLB in 9%, and dementia of unknown etiology in 13% [270], confirming the notion that a high percentage of demented persons aged 80+ do not meet the pathological criteria of AD or were classified as "dementia of unknown etiology" [97,276,277]. A 90+ study revealed significantly less severe Aβ, αSyn and TP'D-43 pathologies and hippocampal lesions in non-demented subjects, while Aβ distribution showed no esssential differences; non-demented individuals had limited hippocampal tau and neocortical Aβ pathology [241].…”

Challenges in the Neuropathological Diagnosis of Dementias

“…4). In a prospective study of 180 demented patients (mean age 85±3.4 years), autopsy showed AD in 48%, AD with vascular pathology in 19%, VaD in 11%, DLB in 9%, and dementia of unknown etiology in 13% (Jellinger and Attems, 2010), confirming the notion that a high percentage of demented persons aged 80+ do not met the pathological criteria of AD or were classified as "dementia of unknown etiology" (Crystal et al, 2000;Jellinger, 2001). Non-AD pathology significantly improved precise differentiation between oldest-old and younger age groups (Middleton et al, 2011).…”

CT Brain Findings in Clinical Dementia Investigation – Underestimation of Mixed Dementia

“…Recent studies found that a significant percentage of demented elderly patients did not meet the pathological criteria for AD [9,10], and in a considerable number of clinical VaD cases, postmortem examination showed a mixed dementia or even pure AD [11]. One third of AD patients exhibited vascular lesions, and a similar proportion of patients with VaD had pathological changes consistent with AD [12].…”

Neuropathology of Dementia Disorders

“…VaD showed a continuing age-related decrease from 15.6 to 9.4% (p<0.05), whereas AD + Lewy pathology remained fairly stable (10.3 and 11%). In a prospective study of 180 demented patients (mean age 85 ± 3.4 years), autopsy showed AD in 48%, AD with vascular pathology in 19%, VaD in 11%, DLB in 9%, and dementia of unknown etiology in 13% [270], confirming the notion that a high percentage of demented persons aged 80+ do not meet the pathological criteria of AD or were classified as "dementia of unknown etiology" [97,276,277]. A 90+ study revealed significantly less severe Aβ, αSyn and TP'D-43 pathologies and hippocampal lesions in non-demented subjects, while Aβ distribution showed no esssential differences; non-demented individuals had limited hippocampal tau and neocortical Aβ pathology [241].…”

Challenges in the Neuropathological Diagnosis of Dementias

“…4). In a prospective study of 180 demented patients (mean age 85±3.4 years), autopsy showed AD in 48%, AD with vascular pathology in 19%, VaD in 11%, DLB in 9%, and dementia of unknown etiology in 13% (Jellinger and Attems, 2010), confirming the notion that a high percentage of demented persons aged 80+ do not met the pathological criteria of AD or were classified as "dementia of unknown etiology" (Crystal et al, 2000;Jellinger, 2001). Non-AD pathology significantly improved precise differentiation between oldest-old and younger age groups (Middleton et al, 2011).…”

CT Brain Findings in Clinical Dementia Investigation – Underestimation of Mixed Dementia

“…Recent studies found that a significant percentage of demented elderly patients did not meet the pathological criteria for AD [9,10], and in a considerable number of clinical VaD cases, postmortem examination showed a mixed dementia or even pure AD [11]. One third of AD patients exhibited vascular lesions, and a similar proportion of patients with VaD had pathological changes consistent with AD [12].…”

Neuropathology of Dementia Disorders

“…VaD showed a continuing age-related decrease from 15.6 to 9.4% (p<0.05), whereas AD + Lewy pathology remained fairly stable (10.3 and 11%). In a prospective study of 180 demented patients (mean age 85 ± 3.4 years), autopsy showed AD in 48%, AD with vascular pathology in 19%, VaD in 11%, DLB in 9%, and dementia of unknown etiology in 13% [270], confirming the notion that a high percentage of demented persons aged 80+ do not meet the pathological criteria of AD or were classified as "dementia of unknown etiology" [97,276,277]. A 90+ study revealed significantly less severe Aβ, αSyn and TP'D-43 pathologies and hippocampal lesions in non-demented subjects, while Aβ distribution showed no esssential differences; non-demented individuals had limited hippocampal tau and neocortical Aβ pathology [241].…”

Challenges in the Neuropathological Diagnosis of Dementias

“…4). In a prospective study of 180 demented patients (mean age 85±3.4 years), autopsy showed AD in 48%, AD with vascular pathology in 19%, VaD in 11%, DLB in 9%, and dementia of unknown etiology in 13% (Jellinger and Attems, 2010), confirming the notion that a high percentage of demented persons aged 80+ do not met the pathological criteria of AD or were classified as "dementia of unknown etiology" (Crystal et al, 2000;Jellinger, 2001). Non-AD pathology significantly improved precise differentiation between oldest-old and younger age groups (Middleton et al, 2011).…”

CT Brain Findings in Clinical Dementia Investigation – Underestimation of Mixed Dementia

“…Recent studies found that a significant percentage of demented elderly patients did not meet the pathological criteria for AD [9,10], and in a considerable number of clinical VaD cases, postmortem examination showed a mixed dementia or even pure AD [11]. One third of AD patients exhibited vascular lesions, and a similar proportion of patients with VaD had pathological changes consistent with AD [12].…”