Frequency of Automatic Stimulations in Responsive Vagal Nerve Stimulation in Patients With Refractory Epilepsy

VNS parameters for clinical response in Epilepsy

“…This bias risk in our retrospective analysis is further exacerbated by VNS clinical practice habits, as patients who are not yet responding to VNS are often programmed to higher duty cycles e resulting in those who may never respond to VNS receiving higher duty cycles. Can the use of higher duty cycles, either by techniques like rapid cycling or the implementation of lowthreshold responsive VNS [33], provide better outcomes? While our model concludes that this is not the case, results of various prospective and retrospective studies are not concordant, and this issue should be explored in prospective studies such as the CORE-VNS registry (NCT03529045).…”