Frequency-domain EEG source analysis for acute tonic cold pain perception

Shao, Shiyun; Shen, Ka; Yu, Ke; Wilder-Smith, Einar; Li, Xiaoping

doi:10.1016/j.clinph.2012.02.084

Cited by 105 publications

(121 citation statements)

References 46 publications

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“…5 Human electroencephalographic (EEG) recording studies together with source localization analysis of generators have: i) confirmed the presence and sub-second activation pattern of brain structures tied to pain intensity processing, 6 ii) shown that individual differences in pain sensitivity partly depend on individual differences in the early activation response of the precuneus, 7 iii) demonstrated that the primary somatosensory cortex, when activated soon after a painful stimulus, does indeed participate in the processing of painful experiences, 8 and, iv) shown that regulatory areas of the orbitofrontal cortex and amygdala participate in the initial activation and control of descending bulbo-spinal pain inhibition circuits. 9 Although these studies are useful in their ability to highlight how the human brain responds to painful experiences, they have only considered neuronal networks which oscillate in phase to painful afferent volleys.…”

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confidence: 99%

Significance of Non-phase Locked Oscillatory Brain Activity in Response to Noxious Stimuli

Rouleau

Lagrandeur

Daigle

et al. 2015

Can. J. Neurol. Sci.

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Background: Although current pain-evoked electroencephalographic (EEG) studies provide valuable information regarding human brain regions involved in pain, they have mostly considered neuronal responses which oscillate in phase following a painful event. In many instances, cortical neurons respond by generating bursts of activity that are slightly out of phase from trial-to-trial. These types of activity bursts are known as induced brain responses. The significance of induced brain responses to pain is still unknown. Methods: In this study, 23 healthy subjects were given both non-painful and painful transcutaneous electrical stimulations in separate testing blocks (stimulation strength was kept constant within blocks). Subjective intensity was rated using a numerical rating scale, while cerebral activity tied to each stimulation was measured using EEG recordings. Induced brain responses were identified using a time frequency wavelet transform applied to average-removed single trials. Results: Results showed a pain-specific burst of induced theta activity occurring between 180 and 500 ms post-shock onset. Source current density estimations located this activity within the dorsolateral prefrontal cortex (DLPFC, bilaterally), however, only right DLPFC activity predicted a decrease in subjective pain as testing progressed. Conclusion: This finding suggests that non-phase locked neuronal responses in the right DLPFC contribute to the endogenous attenuation of pain through time. Perspective: This article presents neuroimaging findings demonstrating that, in response to pain, non-phase locked bursts of theta activity located in the right dorsolateral prefrontal cortex are associated with a progressive decrease in subjective pain intensity, which has potentially important implications regarding how humans endogenously control their experiences of pain. RÉSUMÉ: Signification de l'activité cérébrale induite en réponse aux stimuli douloureux. Contexte: Bien que les études électroencéphalographiques concernant la réponse à la douleur fournissent des informations précieuses sur les régions du cerveau humain impliquées dans la perception de la douleur, elles portent surtout sur les réponses neuronales qui oscillent en phase après un événement douloureux. Dans plusieurs cas, les neurones corticaux répondent en générant de l'activité qui est légèrement déphasée d'une fois à l'autre. Ce type d'activité est appelé réponse cérébrale induite. La signification des réponses cérébrales induites par un évènement douloureux demeure inconnue. Méthode: Cette étude porte sur 23 sujets sains soumis à des blocs séparés de stimulation électrique transcutanée non douloureuse et douloureuse. La force de la stimulation demeurait constante à l'intérieur de chacun des blocs de stimulation. Une échelle d'évaluation numérique a été utilisée pour estimer l'intensité de la stimulation ressentie par le sujet pendant que l'activité cérébrale liée à chaque stimulation était mesurée par enregistrement ÉEG. Les réponses cérébrales induites ont ét...

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mentioning

confidence: 99%

Significance of Non-phase Locked Oscillatory Brain Activity in Response to Noxious Stimuli

Rouleau

Lagrandeur

Daigle

et al. 2015

Can. J. Neurol. Sci.

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“…Previous imaging studies have shown increased neuronal activities in these regions under chronic pain conditions (Apkarian et al 2005(Apkarian et al , 2009Brooks and Tracey 2005;Ohara et al 2005), and reduced overactivation during pain relief (Prichep et al 2011;Stern et al 2006). Similarly, multiple brain regions in the pain matrix showed stronger oscillatory activities in the higher frequency range ([12 Hz) but decreased low frequency oscillations (\12 Hz) during noxious stimulation (Dowman et al 2008;Iwata et al 2005;Ploner et al 2006;Shao et al 2012). Thus, it is rational to propose that moxibustion exerts its therapeutic effects through insula-centered cortical circuits.…”

Section: Discussionmentioning

confidence: 99%

“…The tomography sLORETA has received considerable validation from studies combining LORETA with other more established localization methods including functional magnetic resonance imaging (fMRI) (Mulert et al 2004b;Vitacco et al 2002) and positron emission tomography (Dierks et al 2000;Pizzagalli et al 2004;Zumsteg et al 2005). It is now widely used in studies involving time and frequency domain analysis (Shao et al 2012;Volpe et al 2007;Zumsteg et al 2006). …”

Section: Discussionmentioning

confidence: 99%

“…The sLORETA algorithm has been shown to outperform several other linear inverse algorithms (Pascual-Marqui 2002b). It has been widely used in EEG studies (Jaiswal et al 2010;Justen et al 2014;Shao et al 2012), and demonstrated to be a feasible tool for pain research (Nir et al 2008).…”

Section: Methodsmentioning

confidence: 99%

“…The advances in EEG source localization methods have enabled the investigation of electric neuronal activity inside the brain, and provide the possibility to reveal brain areas associated with heat-sensitization responses. Among them, the standardized low-resolution brain electromagnetic tomography (sLORETA) allowing 3-D localization of cortical EEG generators both in the time Ozaki et al 2012) and frequency domain (Houdayer et al 2015;Jaiswal et al 2010;Justen et al 2014), has been successfully applied to electrophysiological characterization of intracranial responses to pain (Shao et al 2012;Stern et al 2006). Recent studies have confirmed sLORETA to accurately localize neural generators of brain electrical activity (Mulert et al 2004a;Pascual-Marqui 2002a;Walla et al 2008).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cortical activities of heat-sensitization responses in suspended moxibustion: an EEG source analysis with sLORETA

Wang

Zhang

et al. 2015

Cogn Neurodyn

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Moxibustion is under active research as a complementary and alternative treatment for various diseases such as pain. ''Heat-sensitization'' responses have been reported during suspended moxibustion, whose occurrence is associated with significantly better therapeutic effects. The present study aimed to investigate the cortical activities of this interesting phenomenon by a standardized low-resolution brain electromagnetic tomography. We performed electroencephalography recording in a group of patients with chronic low back pain before, during, and after moxibustion treatment at Yaoyangguan (DU3) areas. 11 out of 21 subjects experienced strong heatsensitization during moxibustion, which were accompanied with significant decreases of current densities in the beta frequency bands in prefrontal, primary and second somatosensory, and cingulate cortices, as well as increased current densities in the alpha2 band in the left insula. No changes were detected in patients without sensitization responses, or in the post-moxibustion phase of either group. These data indicated widespread activity changes across different frequency bands during heat-sensitization. Cortical oscillatory activities could be used to evaluate the ''heatsensitization'' responses during suspended moxibustion.

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Neuromodulation Management of Chronic Neuropathic Pain in the Central Nervous System

2020

Adv Funct Materials

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Neuromodulation is a clinical tool used for treating chronic neuropathic pain by transmitting controlled physical energy to the pre‐identified neural targets in the central nervous system. Its drug‐free, nonaddictive, and improved targeting characteristics have attracted increasing attention among neuroscience research and clinical practices. This article provides a brief overview of the neuropathic pain and pharmacological routines for treatment, summarizes both the invasive and noninvasive neuromodulation modalities for pain management, and highlights an emerging brain stimulation technology, transcranial focused ultrasound (tFUS), with a focus on ultrasound transducer devices and the achieved neuromodulation effects and applications on pain management. Practical considerations of spatial guidance for tFUS are discussed for clinical applications. The safety of transcranial ultrasound neuromodulation and its future prospectives on pain management are also discussed.

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Frequency-domain EEG source analysis for acute tonic cold pain perception

Cited by 105 publications

References 46 publications

Significance of Non-phase Locked Oscillatory Brain Activity in Response to Noxious Stimuli

Significance of Non-phase Locked Oscillatory Brain Activity in Response to Noxious Stimuli

Cortical activities of heat-sensitization responses in suspended moxibustion: an EEG source analysis with sLORETA

Neuromodulation Management of Chronic Neuropathic Pain in the Central Nervous System

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