Frequency and Sites of Distant Metastases in Head and Neck Squamous Cell Carcinoma: An Analysis of 101 Cases at Autopsy

Abstract

\s=b\One hundred one cases of squamous cell carcinoma of the upper respiratory and digestive tracts were analyzed for distant metastases. In all cases, autopsies were performed. Forty (40%) of the 101 patients had presented with one or more distant metastases. The most common sites of distant metastases were the

Clinical parameters predicting development of pulmonary malignancies in patients treated for head and neck squamous cell carcinoma

“…Using multivariate analysis, we showed that locoregional failure and current smoking are independent predictors of pulmonary malignancy. Again, these results are consistent with previous reports . Locoregional failure is indicative of tumor progression and resistance; hence, it is not surprising to identify it as a risk factor for pulmonary malignancy.…”

Distant metastases after transoral laser microsurgery for laryngeal and hypopharyngeal squamous cell carcinoma

“…Five cases of glottic tumors were located in the anterior commissure, a location in which intraoperative control of complete resection is more difficult. These results are consistent with other series of patients who underwent TLM,3, 8 external surgery,20 or multimodality treatment (surgery, radiotherapy, and chemotherapy combinations),21–23 although some authors report that the site of primary tumor did not have a significant influence 24–26…”

Carcinoma of the Oropharynx: Local Failure as the Decisive Parameter for Distant Metastases and Survival

“…We found distant metastases in 14 out of 62 (23%) patients with uncontrolled locoregional tumor, predominantly in the lung, as reported by other authors [25]. In contrast, only 4 out of 77 patients (5%) who were locoregionally cured were found to have distant metastases (p < 0.0026, Table 3).…”