Frequency and prognostic significance of clonal T-cell receptor beta-gene rearrangements in the peripheral blood of patients with mycosis fungoides

Rare occurrence of CD30+ circulating cells in patients with cutaneous CD30+ anaplastic large cell lymphoma: a study of nine patients

“…Accordingly, as for circulating CD30+ cells, the detection of a dominant T‐cell clone in peripheral blood is not clearly related to the extension of the cutaneous lesions. Overall, these results contrast with data obtained from MF when a circulating clone can be detected in more than half of the patients even in the early, plaque‐like stages of the disease 20–25 …”

Clonal disease in extracutaneous compartments in cutaneous T-cell lymphomas. A comparative study between cutaneous T-cell lymphomas and pseudo lymphomas

“…A clonal gene rearrangement in the peripheral blood was detected in 1/23 patients (4%) with plaque stage MF, 2/19 patients (10%) with tumour stage MF and 2/4 patients (50%) with erythrodermic MF. These authors suggested that CTCL patients with peripheral blood involvement have a significantly shorter survival time than patients without peripheral blood involvement [4]. We can speculate that multiple cutaneous involvement of a cutaneous lymphoma with the same T-cell clone is only possible by haematogenous or lymphogenous spread.…”

“…In contrast, in all eight patients with PSL and in the LP patient, no gene rearrangements of TcR β or IgH were detected. Bakels et al [4] found TcR β rearrangements in peripheral blood samples in 5/46 patients (11%) with MF. A clonal gene rearrangement in the peripheral blood was detected in 1/23 patients (4%) with plaque stage MF, 2/19 patients (10%) with tumour stage MF and 2/4 patients (50%) with erythrodermic MF.…”

Systemic involvement in mycosis fungoides

“…A few papers dealing with extracutaneous involvement in MF confirm their findings by autopsies 10,13,[45][46][47][48][49][50][51][52][53] .…”

“…From thisstudy it was concluded, that clonal TCR beta-generearrangements, as detected by Southem blot analysis, are uncommon in the peripheral blood of patients with MF, in particular in patients without histologically documented lymph node involvement 45 . Atypical lymphoma cells in the peripheral blood smear were detected in 22 of 115 (19%) patients, only 12 of which (10%) had 5% or more atypical lymphoma (or Sézary) cells [81].…”