Frequency and Patterns of Metastatic Disease in Locally Advanced Inflammatory and Non-inflammatory Breast Cancer

Value of routine staging imaging studies for patients with stage III breast cancer

“…Due to the greater likelihood of detecting asymptomatic metastatic disease with increasing tumor size, increasing nodal involvement, and IBC, the European Society for Medical Oncology (ESMO) guidelines recommend RSIS in patients with clinically positive axillary nodes and tumors ≥5 cm . According to ESMO guidelines, RSIS should also be considered prior to planned neoadjuvant chemotherapy .…”

Aggressive Subsets of Metastatic Triple Negative Breast Cancer

“…This supports a previously published study, wherein patients with IBC had a significantly greater frequency of metastases to the pleural space relative to patients without IBC. 26 This pattern suggests a possible tropism for the pleural space in addition to the established extensive lymphatic involvement of the locoregional area. In comparison, we did not observe distinct patterns of metastatic sites when comparing young patients without IBC with patients with IBC who were diagnosed above the age of 45 years.…”

“…Among patients with metastatic TNBC in our current singleinstitution cohort, those diagnosed with IBC and young patients without IBC had significantly worse overall survival compared with patients over 45 years without IBC. Most studies evaluate either patients with IBC or young patients, 1,5,7,26 yet these data suggest that both subsets reflect a worse prognosis and, importantly, these analyses were within a single subtype (TNBC) and only included patients with metastatic disease. One caveat is that this is a nonepopulation-based cohort that may be potentially impacted by referral or study enrollment bias; however, these data support further analyses within these subsets.…”

Social media in cancer care

“…Indeed, patients with LABC have a higher risk of development of metastatic disease [5], and guidelines suggest that one aim of neoadjuvant treatment in such patients is to decrease the risk of metastatic spread [6]. Generally, this occurs routinely when clinic visits are documented in the patient's chart or recorded in the form of dictated notes from clinicians, which are then copied to all clinicians involved in that patient's care.…”