Frequency and functional activity of Th17, Tc17 and other T-cell subsets in Systemic Lupus Erythematosus

Henriques, Ana; Inês, Luís; Couto, Maura; Pedreiro, Susana; Santos, Catarina; Magalhães, Mariana; Santos, Paulo Sérgio da Silva; Velada, Isabel; Almeida, Anabela; Carvalheiro, Tiago; Laranjeira, Pires; Morgado, José Mário; Pais, Maria Luísa; Silva, José António Pereira da; Paiva, Artur

doi:10.1016/j.cellimm.2010.05.004

Cited by 84 publications

(80 citation statements)

References 49 publications

(60 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3). Actually, in line with the notable cytokine profile plasticity presented by normal peripheral Th17 cells and taking into account the enhancement of Th2 cell function found previously by us in active SLE patients, [28] along with the miscellaneous immunosuppressive drugs received by those patients [29,30], a suppressive effect may be exerted on Th17 polyfunctional effector phenotype, resulting in a decrease proportion of those subpopulations expressing TNF-α/IL-2 and TNF-α. Especially, those findings may point to the strong fidelity lineage of Th17 in active disease SLE or even a terminal differentiation stage related with a repeated antigen challenge as compared to inactive SLE or normal control groups.…”

Section: Discussionsupporting

confidence: 67%

Th17 cells in systemic lupus erythematosus share functional features with Th17 cells from normal bone marrow and peripheral tissues

et al. 2011

Self Cite

View full text Add to dashboard Cite

This study was designed to investigate the functional heterogeneity of human Th17 and how their plasticity shapes the nature of immune cell responses to inflammation and autoimmune diseases, such as systemic lupus erythematosus (SLE). We evaluated functional Th17 cell subsets based on the profile of cytokine production in peripheral blood (PB), bone marrow aspirates (BM) and lymph node biopsies (LN) from healthy individuals (n=35) and PB from SLE patients (n=34). Data were analysed by an automated method for merging and calculation of flow cytometric data, allowing us to identify eight Th17 subpopulations. Normal BM presented lower frequencies of Th17 (p=0.006 and p=0.05) and lower amount of IL-17 per cell (p=0.03 and p=0.02), compared to normal PB and LN biopsies. In the latter tissues were found increased proportions of Th17 producing TNF-α or TNF-α/IL-2 or IFN-γ/TNF-α/IL-2, while in BM, Th17 producing other cytokines than IL-17 was clearly decreased. In SLE patients, the frequency of Th17 was higher than in control, but the levels of IL-17 per cell were significantly reduced (p<0.05). Among the eight generated subpopulations, despite the great functional heterogeneity of Th17 in SLE, a significant low proportion of Th17 producing TNF-α was found in inactive SLE, while active SLE showed a high proportion producing only IL-17. Our findings support the idea that the functional heterogeneity of Th17 cells could depend on the cytokine microenvironment, which is distinct in normal BM as well as in active SLE, probably due to a Th1/Th2 imbalance previously reported by our group.

show abstract

Section: Discussionsupporting

confidence: 67%

Th17 cells in systemic lupus erythematosus share functional features with Th17 cells from normal bone marrow and peripheral tissues

et al. 2011

Self Cite

View full text Add to dashboard Cite

show abstract

“…Recently, a subpopulation of CD8 + T cells, a cell subset producing IL-17 (Tc17), was also discovered. [5][6][7] In addition, Henriques et al [8] reported that a trend for increased proportion in Tc17 cells was found in systemic lupus erythematosus (SLE) patients when they were compared with healthy controls. Furthermore, Ortega et al [9] showed that IL-17-producing CD8 + T lymphocytes from psoriasis skin plaques are cytotoxic effector cells that secrete Th17-related cytokines.…”

Section: Discussionmentioning

confidence: 99%

Elevated CD8+ IL-17+ Tc17 Levels and Their Correlation with Disease Activity in Patients with Rheumatoid Arthritis

Han

Zhou

et al. 2013

Turk J Rheumatol

View full text Add to dashboard Cite

“…Th17 cells have been implicated in the pathogenesis of several human autoimmune diseases and inflammatory disease models via proinflammatory cytokines production [20][21][22][23]. On the other hand, Th17 cells play an important role in host defense against extracellular bacteria and parasites [24].…”

Section: Gut Microbiota and Th17mentioning

confidence: 99%

Interplay between Gut Microbiota and T Lymphocytes in Colorectal Cancer

Hetta¹,

Elkady²,

Mekky³

et al. 2017

Colorec Cancer

View full text Add to dashboard Cite

Colorectal cancer is one of the third leading causes of cancer mortality worldwide. There is increasing evidences about the involvement of gut microbiota in colorectal carcinogenesis. Several recent studies have shed light on the cross talk between gut microbiota and mucosal T cell subsets, specifically intraepithelial lymphocytes and lamina propria CD4 + T cells including T-helper cells and Tregulatory (Treg) cells which may be responsible for development of colorectal cancer through creating imbalance between proinflammatory and antiinflammatory immune cells and their cytokines. In this review, we will focus on the influence gut microbiota on the development of mucosal T cells and their role in promoting colorectal cancer.

show abstract

Frequency and functional activity of Th17, Tc17 and other T-cell subsets in Systemic Lupus Erythematosus

Cited by 84 publications

References 49 publications

Th17 cells in systemic lupus erythematosus share functional features with Th17 cells from normal bone marrow and peripheral tissues

Th17 cells in systemic lupus erythematosus share functional features with Th17 cells from normal bone marrow and peripheral tissues

Elevated CD8+ IL-17+ Tc17 Levels and Their Correlation with Disease Activity in Patients with Rheumatoid Arthritis

Interplay between Gut Microbiota and T Lymphocytes in Colorectal Cancer

Contact Info

Product

Resources

About