Frequency and Antibiotic Susceptibility of Pseudomonas aeruginosa and Acinetobacter baumannii Infections in Pediatrics Intensive Care Unit of Imam Ali Hospital, Karaj, Iran During 2017- 2018

Abstract

<jats:p>Background: Pseudomonas aeruginosa and Acinetobacter baumannii are widely ubiquitous in nature. In addition, they are opportunistic pathogens for humans and the common cause of nosocomial infections. Objective: Due to the increased antibiotic resistance in the treatment of nosocomial infections, this study aimed to evaluate the antibiotic susceptibility pattern of P. aeruginosa and A. baumannii in the pediatrics intensive care unit (PICU). Materials and Methods: Totally, 280 clinical samples from PICU patients were evaluated in this study. The samples were examined for P. aeruginosa and A. baumannii using standard microbiological methods. Finally, the Epsilometer test method was performed to investigate the antibiotic susceptibility pattern of these bacteria. Results: The results revealed a total of 21 isolates (7.5%) of P. aeruginosa and 11 isolates (3.9%) of A. baumannii. P. aeruginosa isolates showed the highest susceptibility to colistin (85.7%) and gentamicin (66.7%) while A. baumannii isolates were more susceptible to colistin (100%), ceftazidime (54.5%), and amikacin (45.5%), respectively. Conclusion: Due to the antibiotic susceptibility patterns of bacterial isolates in the recent study, colistin and gentamicin are recommended for the treatment of P. aeruginosa infections and colistin, ceftazidime, and amikacin are suggested for A. baumannii infections.</jats:p>

Expression of Biofilm-Related Genes in Extensively Drug-Resistant Acinetobacter baumannii

“…In this study, the isolated strains from patients hospitalized in the ICU demonstrated resistance to a broad spectrum of antibiotics. This observation aligns with previous studies that have reported the high resistance of A. baumannii isolates to various antimicrobial agents in neurosurgical and neonatal ICUs (40)(41)(42). Efflux pumps, such as adeA and adeS, are recognized as significant mechanisms of resistance in A. baumannii, as they actively expel toxic substances, including antibiotics, from the bacterial cell (43).…”

Evaluating the Activity of Ultrasound on Biofilm Formation by Acinetobacter baumannii isolated from clinical Specimens

“…In addition, of the 66 clinical A. baumannii isolates evaluated, 1.5 % were qualified as PDR, 72.7 % were designed as XDR and 16.7 %, were qualified as MDR, whereas, 85.6 % of A. baumannii isolates were designed as MDR, and 14.4% were qualified as XDR about 31 . The resistance phenotype of Gram negative bacteria in urine is diverse, among all isolates in urine 35, 62.8 % were qualified as MDR, and 28.5 % were qualified as XDR.…”