French infant total diet study: Exposure to selected trace elements and associated health risks

Sirot, Véronique; Traore, Thiéma; Guérin, Thierry; Noël, Laurent; Bachelot, Morgane; Cravedi, Jean Pierre; Mazur, Andrzej; Glorennec, Philippe; Vasseur, Paule; Jean, Julien; Carne, Géraldine; Gorecki, Sébastien; Rivière, Gilles; Hulin, Marion

doi:10.1016/j.fct.2018.07.062

Cited by 38 publications

(15 citation statements)

References 28 publications

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“…The results from the French TDS and iTDS (ANSES 2011(ANSES , 2016Sirot et al 2018), covering the age between < 1 month and 14 years, are presented in Tables 4 and 5. The mean aluminium intake increases from 0.21 to 0.37 mg/kg bw/week (LB) in the first 36 months.…”

Section: Dietary Aluminium Intake For Infants Toddlers and Childrenmentioning

confidence: 99%

“…In the 90th percentile, the intake increases from 0.43 to 0.61 mg/kg bw/week (LB). According to the authors, the increase results from the stepwise inclusion of additional food products in the daily diet (Sirot et al 2018). Infant formula is the main source of aluminium intake until the 4th month (85%).…”

Section: Dietary Aluminium Intake For Infants Toddlers and Childrenmentioning

confidence: 99%

“…Infant formula is the main source of aluminium intake until the 4th month (85%). Afterwards, follow-on formulas, ready-to-eat vegetable meals for children, and vegetables (excluding potatoes) become increasingly important (> 10%) (Sirot et al 2018). The resulting average dietary aluminium intake corresponds to 21-37% of the TWI derived by EFSA.…”

Section: Dietary Aluminium Intake For Infants Toddlers and Childrenmentioning

confidence: 99%

“…Long-term aluminium intake in different age groups. Data basis: French iTDS, second French TDS(ANSES 2011(ANSES , 2016Sirot et al 2018) and German pilot TDS. Upper bound estimates for the age group 1-36 months and 14-80 years and middle bound estimates for the age group 3mg Al/kg bw/week.…”

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confidence: 99%

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Aggregated aluminium exposure: risk assessment for the general population

et al. 2019

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Aluminium is one of the most abundant elements in earth's crust and its manifold uses result in an exposure of the population from many sources. Developmental toxicity, effects on the urinary tract and neurotoxicity are known effects of aluminium and its compounds. Here, we assessed the health risks resulting from total consumer exposure towards aluminium and various aluminium compounds, including contributions from foodstuffs, food additives, food contact materials (FCM), and cosmetic products. For the estimation of aluminium contents in foodstuff, data from the German "Pilot-Total-Diet-Study" were used, which was conducted as part of the European TDS-Exposure project. These were combined with consumption data from the German National Consumption Survey II to yield aluminium exposure via food for adults. It was found that the average weekly aluminium exposure resulting from food intake amounts to approx. 50% of the tolerable weekly intake (TWI) of 1 mg/kg body weight (bw)/week, derived by the European Food Safety Authority (EFSA). For children, data from the French "Infant Total Diet Study" and the "Second French Total Diet Study" were used to estimate aluminium exposure via food. As a result, the TWI can be exhausted or slightly exceeded-particularly for infants who are not exclusively breastfed and young children relying on specially adapted diets (e.g. soy-based, lactose free, hypoallergenic). When taking into account the overall aluminium exposure from foods, cosmetic products (cosmetics), pharmaceuticals and FCM from uncoated aluminium, a significant exceedance of the EFSA-derived TWI and even the PTWI of 2 mg/kg bw/week, derived by the Joint FAO/WHO Expert Committee on Food Additives, may occur. Specifically, high exposure levels were found for adolescents aged 11-14 years. Although exposure data were collected with special regard to the German population, it is also representative for European and comparable to international consumers. From a toxicological point of view, regular exceedance of the lifetime tolerable aluminium intake (TWI/PTWI) is undesirable, since this results in an increased risk for health impairments. Consequently, recommendations on how to reduce overall aluminium exposure are given. Article Highlights • Risk assessment of total aluminium exposure from different sources for different age groups. • Use of data from the European TDS-Exposure project for the estimation of aluminium exposure from foodstuff. • Comprehensive overview of the toxicological properties of aluminium.

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Section: Dietary Aluminium Intake For Infants Toddlers and Childrenmentioning

confidence: 99%

Section: Dietary Aluminium Intake For Infants Toddlers and Childrenmentioning

confidence: 99%

Section: Dietary Aluminium Intake For Infants Toddlers and Childrenmentioning

confidence: 99%

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confidence: 99%

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Aggregated aluminium exposure: risk assessment for the general population

et al. 2019

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“…The contents of PCDD/Fs and trace elements were determined in a wide range of environmental and biological samples [3][4][5][6][7][8][9]. Because diet is the most important route of exposure to these chemicals [10][11][12], the dietary intake by the local population was also evaluated [13,14]. The biomonitoring was based on the analysis of 11 trace elements in samples of hair from schoolchildren, blood from general population, as well as samples of autopsy tissues from individuals who had been residing near the plant for at least the last 10 years [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Biomonitoring of Trace Elements in Subjects Living Near a Hazardous Waste Incinerator: Concentrations in Autopsy Tissues

Garcı́a

Marquès

Barbería

et al. 2020

Toxics

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The only hazardous waste incinerator (HWI) in Spain started to operate in 1999. Twenty years later, the levels of 11 trace elements (As, Be, Cd, Cr, Hg, Mn, Ni, Pb, Sn, Tl and V) were analyzed in five different autopsy tissues (kidney, liver, brain, bone and lung) from 20 individuals who had been living near the facility. In 2019, As, Be, Tl and V were not detected in any of the analyzed tissues, while Hg could be only quantified in very few samples. The highest levels of Cd and Pb were found in kidney and bone, respectively, while those of Mn were observed in liver and kidney. In turn, the mean concentrations of Cr and Sn were very similar in all tissues. A consistent temporal trend was only found for Cr and Pb. On the one hand, the mean Cr concentrations in kidney and bone have increased progressively since 1998. In contrast, the mean levels of Pb decreased significantly over time, probably due to ban of Pb as gasoline additive. The data global analysis indicates that the emissions of trace elements by the HWI have not increased the exposure and/or accumulation of these elements in individuals living near the facility.

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