2009
DOI: 10.1371/journal.pone.0006874
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Abstract: BackgroundThe functional significance of proenkephalin systems in processing pain remains an open question and indeed is puzzling. For example, a noxious mechanical stimulus does not alter the release of Met-enkephalin-like material (MELM) from segments of the spinal cord related to the stimulated area of the body, but does increase its release from other segments.Methodology/Principal FindingsHere we show that, in the rat, a noxious mechanical stimulus applied to either the right or the left hind paw elicits … Show more

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Cited by 2 publications
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“…Although the molecular basis for this change is unclear, opioidergic modulation of dopamine efflux in the dorsal horn can be considered as a potential mechanism. Consistent with this view is the fact that opioids can influence dopamine release in the CNS [71][72][73] and promote the release of endogenous MOR ligands (such as met-enkephalin) that are present in superficial laminae of the dorsal horn [50] and are known to be promoted by noxious stimulation [16,42]. This suggests that an important determinant of D2R-mediated modulation may be endogenous MOR activity, which becomes tonically active after SNL while showing negligible activity basally [15].…”
Section: D2r-mediated Modulation Requires Co-activation Of Mor After mentioning
confidence: 93%
“…Although the molecular basis for this change is unclear, opioidergic modulation of dopamine efflux in the dorsal horn can be considered as a potential mechanism. Consistent with this view is the fact that opioids can influence dopamine release in the CNS [71][72][73] and promote the release of endogenous MOR ligands (such as met-enkephalin) that are present in superficial laminae of the dorsal horn [50] and are known to be promoted by noxious stimulation [16,42]. This suggests that an important determinant of D2R-mediated modulation may be endogenous MOR activity, which becomes tonically active after SNL while showing negligible activity basally [15].…”
Section: D2r-mediated Modulation Requires Co-activation Of Mor After mentioning
confidence: 93%