Free radicals, natural antioxidants, and their reaction mechanisms

Nimse, Satish Balasaheb; Pal, Dilipkumar

doi:10.1039/c4ra13315c

Cited by 1,622 publications

(1,253 citation statements)

References 151 publications

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“…[7,9] Nowadays, the attention of medicinal chemists is focused also on the development of the novel antioxidative agents, especially after it has been evidenced that oxidative damage of important biomacromolecules is directly connected with the pathogenesis of various diseases. [11,12] Thus, the reactive oxygen species (ROS) through the damage of cellular biomacromolecules like proteins, lipids or DNA/RNA may be playing an important role in the development of cancer, atherosclerosis, aging or rheumatoid arthritis. [13,14] One of the chain reactions caused by ROS is lipid peroxidation which could generate mutagenic products with carcinogenic properties.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antioxidative Potency of Novel Amidino Substituted Benzimidazole and Benzothiazole Derivatives

Racané¹,

Cindrić²,

Perin³

et al. 2017

Croat. Chem. Acta

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Herein we present the synthesis of versatile amidino substituted benzothiazole 3-10 and benzimidazole 12-19 derivatives substituted with the variable number of hydroxy and methoxy groups. Furthermore, the synthesized compounds were explored for their antioxidative activity in vitro by using three biological assays, namely DPPH, ABTS and FRAP. The obtained results indicated that the variable number of hydroxy groups together with the type of the amidino substituent strongly influenced the antioxidative activity and reducing power of tested compounds. The most promising antioxidative activity showed trihydroxy substituted compounds 6, 10, 15 and 19. In general, it was noticed that unsubstituted amidino group induced the more pronounced activity in comparison to derivatives bearing 2-imidazolinyl group.

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Section: Introductionmentioning

confidence: 99%

Synthesis and Antioxidative Potency of Novel Amidino Substituted Benzimidazole and Benzothiazole Derivatives

Racané¹,

Cindrić²,

Perin³

et al. 2017

Croat. Chem. Acta

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“…Therefore, a free radical is any atom or molecule that has one or more unpaired electrons and for this reason is highly reactive, seeking to acquire electrons from other substances. Free radical scavenger molecules can inhibit or quench free radical reactions and delay or inhibit cellular damage (Nimse and Pal, 2015) and (Young and Woodside, 2001). Glutathione (GSH) is a non-protein free thiol present in high concentrations in living organisms.…”

Section: Discussionmentioning

confidence: 99%

The radiosensitizer effect of 2,6-bis-(2,6 dichlorobenzylidene) cyclohexanone as a selective thiol alkylator on ht29 cell line

Doroudi¹,

KoroushZarei²,

Mohammadi³

et al. 2017

Int j curr adv res

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“…These radicals cause aggregation of protein, degradation of DNA and eventually destroy cell membranes and kill cells. As a result, this process probably increases the possibility of common diseases [3][4][5][6][7]. Antioxidants are believed to play a central role in health care to prevent and scavenge radicals because they can alleviate chronic diseases and degenerate ailments such as cancer, autoimmune disorder, hypertension, atherosclerosis and ageing process [8][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Phenolic Compounds and Antioxidant Activity of Castanopsis phuthoensis and Castanopsis grandicicatricata

Tuyen

Khang

Minh

et al. 2016

ILNS

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Abstract:In this study, total phenolic and flavonoid contents, antioxidant capacity, and phenolic compositions of Castanopsis phuthoensis and Castanopsis grandicicatricata (Fagaceae family) were investigated. It was found that bark extracts were rich of phenolic contents, whereas leaf extracts were abundant of flavonoids. The total phenolics varied from 11.20 to 35.47 mg gallic acid equivalent g -1 dry weight (DW), and the total flavonoids were from 2.24 to 12.55 mg rutin equivalent g -1 DW. The results of antioxidant activity evaluation showed that the DPPH (1,1-diphenyl-2-picryl-hydrazyl) radical scavenging activity of the free phenolic extracts were higher than the bound phenolic extracts. Regarding the reducing power and β-carotene bleaching assays, the free phenolic extracts showed remarkably strong antioxidant capacity that were similar to the levels of the standard BHT (dibutyl hydroxytoluene) did. It could be concluded that free phenolic extracts were more effective in antioxidant activities than bound phenolic extracts. Highly significant correlations were observed between phenolic contents and antioxidant activities (0.813 for DPPH and 0.841 for reducing power). By HPLC analysis, seven phenolic acids were detected including gallic, p-hydroxybenzoic, vanillic, sinapic, p-coumaric, ellagic acids, and vanillin. Of which, gallic, ellagic, and sinapic acids were the most abundant compounds in the two species. The results suggest C. phuthoensis and C. grandicicatricata contain rich sources of natural antioxidants and phenolic compounds which are probably considered in pharmaceutical use.

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Free radicals, natural antioxidants, and their reaction mechanisms

Abstract: The normal biochemical reactions in our body, increased exposure to the environment, and higher levels of dietary xenobiotic's result in the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS).

Cited by 1,622 publications

References 151 publications

Synthesis and Antioxidative Potency of Novel Amidino Substituted Benzimidazole and Benzothiazole Derivatives

Synthesis and Antioxidative Potency of Novel Amidino Substituted Benzimidazole and Benzothiazole Derivatives

The radiosensitizer effect of 2,6-bis-(2,6 dichlorobenzylidene) cyclohexanone as a selective thiol alkylator on ht29 cell line

Phenolic Compounds and Antioxidant Activity of <i>Castanopsis</i> <i>phuthoensis</i> and <i>Castanopsis</i> g<i>randicicatricata</i>

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