Free radical scavenging and anti-proliferative activities of avocado (<i>Persea americana</i> Mill.) seed extract

Vo, Thanh Sang; Le, Phuong Uyen; Ngo, Dai Hung

doi:10.4103/2221-1691.254602

Cited by 21 publications

(10 citation statements)

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“…Although this study suggests that AvoSE–AuNPs exhibited anticancer effects on both Caco-2 and PC-3, this effect was more pronounced in PC-3 cells. The inhibition of cell proliferation and reduction in cell viability of avocado seed has been well documented. ,, A study by Alkhalaf et al revealed % decrease in cell proliferation of human liver (HepG2) and colon (HCT-116) cancer cells after treatment with lipid extract of avocado seeds. , Similarly, Dabas et al demonstrated the cytotoxic effect of AvoSE on prostate (LNCaP), breast (MCF-7), lung (H1299), and colon (HT-29) cells with half maximal inhibitory concentrations ranging from 19 to 132 μg/mL following a 48 h treatment . The anticancer properties of AvoSE are often credited to its constituent bioactive compounds, namely, tannins, phenolics, and flavonoids .…”

Section: Resultsmentioning

confidence: 99%

Anticancer, Antioxidant, and Catalytic Activities of Green Synthesized Gold Nanoparticles Using Avocado Seed Aqueous Extract

et al. 2023

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Disposal of agricultural waste has a negative impact on the environment and human health and may contribute to the greenhouse effect. The field of nanotechnology could provide alternative solutions to upcycle agricultural wastes in a safer manner into high-end value products. Organic waste from plants contain biomaterials that could serve as reducing and capping agents in the synthesis of nanomaterials with enhanced activities for use in biomedical and environmental applications. Persea americana (avocado) is a fruit with a high nutritional value; however, despite its rich phytochemical profile, its seed is often discarded as waste. Therefore, this study aimed to upcycle avocado seeds through the synthesis of gold nanoparticles (AuNPs) and evaluate their anticancer, antioxidant, and catalytic activities. The biosynthesis of avocado seed extract (AvoSE)-mediated AuNPs (AvoSE−AuNPs) was achieved following the optimization of various reaction parameters, including pH, temperature, extract, and gold salt concentrations. The AvoSE−AuNPs were poly-dispersed and anisotropic, with average core and hydrodynamic sizes of 14 ± 3.7 and 101.39 ± 1.4 nm, respectively. The AvoSE−AuNPs showed excellent antioxidant potential in terms of ferric reducing antioxidant power (343.88 ± 0.001 μmolAAE/L), 2,2-diphenyl-1-picrylhydrazyl (128.80 ± 0.0159 μmolTE/L), and oxygen radical absorbance capacity (1822.02 ± 12.6338 μmolTE/L); significantly reduced the viability of Caco-2 and PC-3 cells in a dose-dependent manner; and efficiently reduced 4-nitrophenol (4-NP) to 4-aminophenol. This study demonstrated how avocado seeds, an agricultural waste, can be used as sources of new bioactive materials for the synthesis of AuNPs, which have excellent antioxidant, anticancer, and catalytic activities, showing AvoSE−AuNPs' versatility in various applications. In addition, the AvoSE−AuNPs exhibited good stability and recyclability during the catalytic activity, which is significant because some of the primary issues with the use of metallic NPs as catalysts are around the cost-effectiveness, recovery, and reusability of the catalyst.

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Section: Resultsmentioning

confidence: 99%

Anticancer, Antioxidant, and Catalytic Activities of Green Synthesized Gold Nanoparticles Using Avocado Seed Aqueous Extract

et al. 2023

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“…Avocado seed extract has cytotoxic activity against prostate cancer cells (LNCaP), breast cancer cells (MCF7), colon cancer cells (HT29), and lung cancer cells (H1299) with IC50 values of 42.15 µg/mL, 19.1 µg/mL, 67.6 µg/mL, and 132.2 µg/mL, respectively (Dabas et al, 2019). The n-hexane fraction of avocado seeds at a concentration of 200 µg/mL inhibits 81±3% of lung cancer cells (A549) growth, while the dichloromethane fraction at the same concentration could inhibit the growth of gastric cancer cells (BGC823) of with inhibition rate of 75±2% (Vo et al, 2019). Chloroform extract of avocado seed was able to inhibit the growth of MCF7 cells with IC50 value of 94.87 µg/mL (Widiastuti et al, 2018).…”

Section: Results and Discussion Cytotoxic Testmentioning

confidence: 99%

Cytotoxic and Antiproliferation Activity of n-Hexane Fraction of Avocado seed (Persea americana Mill.) on MCF7 cell

2022

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Avocado seeds, which often end up as food waste, have many health benefits, including anticancer activity. This study aimed to determine the potential cytotoxic activity of avocado seeds against breast cancer cells, MCF7. Avocado seeds were macerated with 96% ethanol and fractionated with n-hexane, chloroform, and ethyl acetate as solvents. Cytotoxic activity of the extract and fractions was tested using the MTT method, while antiproliferation activity and apoptosis of the n-hexane fraction were tested using the doubling time and double staining methods, respectively. The selectivity of the n-hexane fraction was also determined. The results showed that the extract and n-hexane fraction of avocado seeds had cytotoxic activity on MCF7 with IC50 values of 211.2±25 and 47.87±1.5 µg/mL, respectively. The cytotoxic activity of the n-hexane fraction was selective (Selectivity Index = 4.73). The fraction can extend the doubling time to 76.54-77.41 hours. The double staining test results showed red fluorescence in the cells, indicating the apoptosis of MCF7 cells. The n-hexane fraction of avocado seed extract has the potential to be developed as an anticancer therapeutic agent.

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“…Therefore, here, it is reported, for the first time, the preparation of cadmium sulfide nanoparticles from avocado peel extract. Avocado is an active fruit contains many bioactive compounds such as phenols, hydroxybenzoic acid and flavonoid, [32], which is possibly serve as a capping agent to prevent or reduce the aggregation of CdS nanoparticles and control their stability.…”

Section: Resultsmentioning

confidence: 99%

Green Synthesis of CdS Nanoparticles using Avocado Peel Extract

2022

NanoWorld J

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CdS nanometre-sized particles have been prepared using an eco-friendly and low-cost method. This method relies on using parts of plants as reducing agents and protecting agents. Here, the synthesis of CdS nanoparticles using avocado peel extract, which converts Cd 2+ to Cd atoms and then forms CdS nanoparticles, has been reported. The influence of pH, concentration of peel extract, and reaction time on the formation process of as-prepared CdS nanoparticles were studied. The structural properties of CdS nanoparticles were investigated using electron microscopic techniques (FE-SEM and TEM), and a majority of CdS particles with elongated to spherical shapes were observed. The crystalline structure of CdS nanoparticles (Face Center Cubic-FCC) was confirmed using X-ray diffraction, and the particle size was estimated from the Scherrer equation at nearly 2.5 nm.

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Free radical scavenging and anti-proliferative activities of avocado (Persea americana Mill.) seed extract

Cited by 21 publications

References 1 publication

Anticancer, Antioxidant, and Catalytic Activities of Green Synthesized Gold Nanoparticles Using Avocado Seed Aqueous Extract

Anticancer, Antioxidant, and Catalytic Activities of Green Synthesized Gold Nanoparticles Using Avocado Seed Aqueous Extract

Cytotoxic and Antiproliferation Activity of n-Hexane Fraction of Avocado seed (Persea americana Mill.) on MCF7 cell

Green Synthesis of CdS Nanoparticles using Avocado Peel Extract

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