Free Radical Damage in Nasal Polyp Tissue

Doğru, Harun; Delibaş, Namık; Döner, Fehmi; Tüz, Mustafa; Uygur, Kemal

doi:10.1067/mhn.2001.115086

Cited by 31 publications

(46 citation statements)

References 15 publications

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“…Dogru et al 15 reported that malondialdehyde levels were higher in nasal polyposis than in control mucosa and Dagli et al 3 showed higher malondialdehyde levels in nasal polyp tissue and blood of patients with nasal polyposis compared with control individuals. Malondialdehyde results from the action of free radical damage to cellular lipids and leads to increased levels of free radicals; both free radicals and malondialdehyde injure cell membranes.…”

Section: Discussionmentioning

confidence: 99%

The Association of Oxidative Stress and Nasal Polyposis

et al. 2009

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Many diseases are linked to damage from reactive oxygen species that occurs from an imbalance between reactive oxygen species and antioxidants, a condition called oxidative stress. Nasal polyposis is considered to be an inflammatory condition in nasal and paranasal sinus cavities and its aetiology is still unclear. There are very few data on epithelial changes in nasal polyposis and their relationship with free radical damage. Malondialdehyde as a major end-product of lipid peroxidation, and superoxide dismutase and nitric oxide as antioxidants play important roles in oxidative stress. In this study, the concentrations of malondialdehyde, superoxide dismutase and nitric oxide were compared in normal and nasal polyposis-affected tissue samples. Malondialdehyde levels were significantly higher, and superoxide dismutase and nitric oxide levels were significantly lower in patients with nasal polyposis compared with the control group. This study demonstrates that there is a strong relationship between oxidative stress and the pathogenesis of nasal polyposis.

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Section: Discussionmentioning

confidence: 99%

The Association of Oxidative Stress and Nasal Polyposis

et al. 2009

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“…MPO is an enzyme, which occurs as a result of neutrophil activation, may lead to the formation of FOR such as H 2 O 2 , NO and especially, HOCL with other enzymes [13,14]. Several studies were performed to investigate the relationship of MPO with chronic sinusitis, role of FOR in the development of nasal polyps and the effects of antioxidant agents on the development of nasal polyps [7,15,16]. In a study carried out by Demoly et al regarding neutrophil infiltration in patients diagnosed with chronic investigators demonstrated the production of FOR in the neutrophils of nasal polyps and determined a very high ratio of FOR production in nasal polyps [16].…”

Section: Discussionmentioning

confidence: 99%

“…FOR are necessary for normal immune defense and metabolic activity in humans but also they may cause tissue damage if they are excessively produced and they may play an important role in the pathogenesis of various diseases [6,7]. Currently, there are several studies related with nasal polyps and their relationship with FOR [8,9] but up to date and as much as we are informed, there are a limited number of direct studies related with the role of myeloperoxydase(MPO) which is responsible in the formation of FOR, in the pathogenesis of polyps [10].…”

Section: Introductionmentioning

confidence: 99%

Myeloperoxydase Expression in The Pathogenesis of Nasal Polyps

Sarisoy

Eken²,

Oktay

et al. 2011

Indian J Otolaryngol Head Neck Surg

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Nasal polyps are benign mucosal protrusions that expand into the nasal cavity. There are no any etiological factors that may explain the pathogenesis of nasal polyps but currently inflammation continues to be the major factor. As a result of inflammation, neutrophils become activated and migrate to the inflammatory area and form their bactericidal effects by producing free oxygen radicals. The objective of our study is to investigate the expression of myeloperoxydase enzyme, which is usually an indicator of leukocyte infiltration and is responsible in the formation of free oxygen radicals in polyp tissues and to determine its role in the pathogenesis of nasal polyps.

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“…GSTM1 and GSTT1 genotyping GSTM1 and GSTT1 allele genotyping was carried out by using a multiplex PCR protocol (18). Briefly, the amplification was made in a total volume of 25 µl reaction mixture containing 12.5 µl 2xPCR Master Mix (Thermo Fischer Scientific Inc., MA, USA), 10 pmoles of each forward and reverse specific primers and free nucleases water to 25 µl.…”

Section: Methodsmentioning

confidence: 99%

Comparative analysis of GSTM1/GSTT1 null alleles and Ile105Val GSTP1 variant in patients with Nasal Polyposis and hyposmia in a Romanian population group

Catana¹,

Popp²,

Ioan³

et al. 2013

Romanian Review of Laboratory Medicine

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Background. Polymorphisms for genes encoding glutathione S-transferase (GSTM1/GSTT1/GSTP1) might be one of the factors that can influence the variability in susceptibility for 572). Molecular analysis did not reveal an increased frequency for GSTT1 and GSTM1 null alleles in the patients group compared to controls (GSTT1 -95% CI = 0.332 to 1.261, p = 0.192, OR = 0.641, χ2 = 2.120, χ2 = 2.017, OR = 0.321, p = 0.062). Significant statistical differences were found when combined were compared between patients and controls (p=0.0015, OR=4.0351; OR=3.455,

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Free Radical Damage in Nasal Polyp Tissue

Abstract: High level of MDA in nasal polyp tissue that represents FR increase supports the existence of cell injury in nasal polyp tissue. FRs should be considered in the development and life cycles of NP which is thought to have multifactorial pathogenesis.

Cited by 31 publications

References 15 publications

The Association of Oxidative Stress and Nasal Polyposis

The Association of Oxidative Stress and Nasal Polyposis

Myeloperoxydase Expression in The Pathogenesis of Nasal Polyps

Comparative analysis of GSTM1/GSTT1 null alleles and Ile105Val GSTP1 variant in patients with Nasal Polyposis and hyposmia in a Romanian population group

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