volume 8, issue 1, P50-57 2016
DOI: 10.18632/aging.100863
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Arnaud Tauffenberger, Alexandra Vaccaro, J. Alex Parker

Abstract: Mitochondrial function is central to longevity and an imbalance in mitonuclear protein homeostasis activates a protective response called the mitochondrial unfolded protein response (UPRmt). Toxic compounds damaging mitochondria trigger the UPRmt, but at sublethal doses these insults extend lifespan in simple animals like C. elegans. Mitochondria are the main energy suppliers in eukaryotes, but it is not known if diet influences the UPRmt. High dietary glucose reduces lifespan in worms, and we show that high d…

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