Fractions of Ageratum conyzoides L. (Compositae) induce mitochondrial-mediated apoptosis in rats: Possible option in monosodium glutamate-induced hepatic and uterine pathological disorder

Olowofolahan, Adeola Oluwakemi; Olorunsogo, Olufunso O.

doi:10.1016/j.jep.2021.114192

Cited by 4 publications

(2 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous work on the plant parts used revealed that X. aethiopica fruit extract induced apoptosis ( Adaramoye et al, 2011 ), displayed cytotoxicity against multi-drug resistant (MDR) cancer cell lines ( Kuete et al, 2013 , Kuete et al, 2015 ) and was also reported to induce MPT pore and Caspase-3 ( Choumessi et al, 2012 , Ribeiro et al, 2021 ). A. conyzoides was also reported to induce mitochondrial-mediated apoptosis ( Olowofolahan & Olorunsogo, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Jatonik polyherbal mixture induced rat liver MMPT pore opening in normal Wistar rat: In vitro and in vivo studies

Folashade,

Boyenle,

Oyedeji

et al. 2024

Chinese Herbal Medicines

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Jatonik polyherbal mixture induced rat liver MMPT pore opening in normal Wistar rat: In vitro and in vivo studies

Folashade,

Boyenle,

Oyedeji

et al. 2024

Chinese Herbal Medicines

View full text Add to dashboard Cite

“…It has been proven that phytochemicals especially those that possess anti-oxidative and anti-inflammatory potentials can inhibit tumor growth [5,6]. Also, bioactive agents from medicinal plants that can induce mitochondrial permeability transition pore (mPT) opening could serve as a potential drug candidate to induce cell death [7,8,9]. "Annona muricata Linn, a medicinal plant is folklorically used in the treatment of tumors and cancers" [10].…”

Section: Introductionmentioning

confidence: 99%

Annona muricata Linn Stem Bark Protects against Uterine Proliferative Disorder Induced by Estradiol Benzoate in Female Rat

Olowofolahan

Dare²,

Adeoye³

et al. 2022

EJMP

Self Cite

View full text Add to dashboard Cite

Aim: The opening of mitochondrial permeability transition (mPT) pore is an important event in the execution of mitochondrial-mediated apoptosis. Some bioactive compounds elicit their chemotherapeutic effects against tumor/cancer cells via the induction of mitochondrial-mediated apoptosis. Annona muricata, a medicinal plant, is folklorically used in the treatment of tumors and cancers. This study therefore aimed at investigating the effect of methanol stem bark extract of Annona muricata (MEAM) on apoptosis via mPT pore and estradiol benzoate (EB)-induced proliferative disorder using female Wistar rats. Methodology: Mitochondria were isolated using differential centrifugation. The mPT pore opening, cytochrome c release and mitochondrial ATPase activity were determined spectrophotometrically. The levels of estrogen (E2), luteinizing hormone (LH), follicle stimulating hormone (FSH), malondialdehyde (MDA) and activities of superoxide dismutase (SOD), glutathione peroxidase (GSH), were determined using ELISA technique. Histological and histochemical assessments of the uterine sections were carried out using standard methods. Phytochemical constituents of MEAM were determined using Gas Chromatography-Mass Spectroscopy (GC-MS). Results: The in vitro results showed a significant induction of mPT pore opening, release of cytochrome c and enhancement of mitochondrial ATPase (mATPase) activity in a concentration-dependent manner. However, oral administration of MEAM did not induce rat uterine mPT pore opening, neither any significant release of cytochrome c nor enhancement of mATPase activity at the dosages used. Interestingly, MEAM reversed the EB-induced increase in E2, LH and FSH. The MEAM also improved the antioxidant milleu by reducing MDA level and increasing the SOD and GSH-Px activities in the treatment groups. Administration of EB induced endometrial hyperplasia in the model group which was mitigated by MEAM in the treatment group. The GC-MS analysis of MEAM revealed the presence of some important phytochemicals that are pharmacological relevant in cancer treatment. Conclusions: This study suggests that the methanol stem bark extract of Annona muricata contains bioactive compounds that protect against EB-induced uterine proliferative disorder in female Wistar rats.

show abstract

Bioconversion of phytotoxic terrestrial weeds into soil conditioning bioproduct through two-stage biodegradation process

Pottipati

Hazarika

Kalamdhad

2023

Biomass Conv. Bioref.

View full text Add to dashboard Cite

Fractions of Ageratum conyzoides L. (Compositae) induce mitochondrial-mediated apoptosis in rats: Possible option in monosodium glutamate-induced hepatic and uterine pathological disorder

Cited by 4 publications

References 38 publications

Jatonik polyherbal mixture induced rat liver MMPT pore opening in normal Wistar rat: In vitro and in vivo studies

Jatonik polyherbal mixture induced rat liver MMPT pore opening in normal Wistar rat: In vitro and in vivo studies

Annona muricata Linn Stem Bark Protects against Uterine Proliferative Disorder Induced by Estradiol Benzoate in Female Rat

Bioconversion of phytotoxic terrestrial weeds into soil conditioning bioproduct through two-stage biodegradation process

Contact Info

Product

Resources

About