Fractional excretion of magnesium and kidney function parameters in nondiabetic chronic kidney disease

Correlation Between Serum Parathormone Levels With Urinary Magnesium Excretion in Patients With Non-Dialytic Chronic Kidney Disease

“…The kidneys are the main organs involved in magnesium homeostasis, since they control its serum concentration mainly by modulating excretion in the urine [8,7]. Studies have shown that the magnesium excretion fraction (FEMg) is a sensitive and useful marker for detecting early abnormalities in the kidney's tubulointerstitial structure [9,10] been utilized like tubular lesion marker even in individuals without chronic kidney disease.…”

“…In the work by Chie Noiri et al [29] with 94 Japanese patients, it was reported that FEMg above 6% would provide a more accurate and non-invasive assessment of the presence of tubulointerstitial nephropathy in a group of patients with nondialysis kidney disease. Another study conducted with 111 adults with CKD in Serbia found that an FEMg value greater than 6.1% would provide a more accurate estimate for the reduction of the glomerular ltration rate (GFR) below 60mL /min/1.73m 2 in patients with CKD and without diabetes [9].…”

“…The calculation of the urinary magnesium excretion fraction was performed using the following formula: [12], where MgU = urinary magnesium; CrS = serum creatinine; MgS = serum magnesium; CrU = urinary creatinine. Values above 6,1% were considered altered [9].…”

<p>Correlation Between Parathyroid Hormone Levels with Urinary Magnesium Excretion in Patients with Non-Dialysis Dependent Chronic Kidney Disease</p>

“…Values above 6.1% were considered altered. 9 The samples of 24-hr urine with a volume below 400mL or with urinary creatinine <15mL/Kg/24h (men) and <10mL/Kg/ 24h (women) were considered due to the possibility of error in the collection.…”

“…7,8 Studies have shown that the magnesium excretion fraction (FEMg) is a sensitive and useful marker for detecting early abnormalities in the kidney's tubulointerstitial structure, like tubular lesion marker even in individuals without chronic kidney disease. 9,10 The importance of Mg is well known, although it has not yet received the necessary attention in clinical practice. As CKD progresses, the levels of PTH increase, which acts as a uremic toxin and can contribute to disorders in the metabolism of minerals.…”