Journal of Chromatography A 2012 DOI: 10.1016/j.chroma.2011.12.061 View full text
Sarah C. Rutan, Joe M. Davis, Peter W. Carr

Abstract: Optimization of comprehensive two-dimensional separations frequently relies on the assessment of the peak capacity of the system. A correction is required for the fact that many pairs of separation systems are to some degree correlated, and consequently the entire separation space is not chemically accessible to solutes. This correction is essentially a measure of the fraction of separation space area where the solutes may elute. No agreement exists in the literature as to the best form of the spatial coverage…

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