Fraction of exhaled nitric oxide and soluble receptors for advanced glycation end products are negatively correlated in children with recurrent wheezing

Li, Yuhong; Wu, Rongqian; Tian, Yian; Bao, Ting; Tian, Zengshan

doi:10.12932/ap0746

Cited by 14 publications

(8 citation statements)

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“…When eosinophils are recruited to the inflammation area, they are activated and release cytokines and cationic proteins, which modulate the immune response. ECP is present in eosinophil granules and has been associated with eosinophil-associated disorders (48). EPO is exclusively synthesized and released by eosinophils (49).…”

Section: Discussionmentioning

confidence: 99%

Galectin-Receptor Interactions Regulates Cardiac Pathology Caused by Trichinella spiralis Infection

2021

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The parasitic nematode Trichinella spiralis causes trichinellosis, a serious food-borne parasitic zoonosis worldwide. Infection with T. spiralis may also cause myocarditis. In the present study, we used mouse models to assess the impact of blockage of galectin-receptor interactions by α-lactose on cardiac immunopathology during acute T. spiralis experimental infection. Our data demonstrated that, after T. spiralis infection, blockage of galectin-receptor interactions resulted in cardiac dysfunction detected by transthoracic conventional echocardiography, and increased serum Gal-3 level, a biomarker of myocardial damage. In addition, there were increased eosinophil number in peripheral blood, and increased eosinophil infiltration in the heart and spleen tissues accompanied with increased mRNA levels of eosinophil granule proteins (including eosinophil cationic protein (ECP) and eosinophil peroxidase (EPO)) and IL-5 in these organs; increased cardiac fibrosis accompanied with increased Gal-3 and collagen 1 expressions in the hearts of mice with blockage of galectin-receptor interactions after T. spiralis infection. Correlation analysis showed that significant positive correlations existed between the mRNA levels of Gal-3 and ECP/EPO/eosinophil major basic protein/IL-5/CCL11/CCR3/α-SMA/collagen 1 in the hearts of both T. spiralis-infected mice and T. spiralis-infected mice with blockage of galectin-receptor interactions. Our data suggest that galectin-receptor interactions play a pivotal role during acute T. spiralis infection, and lack of galectin-receptor interactions upregulates Gal-3 which, in turn, leads to elevated heart eosinophil recruitment, exacerbated heart pathology and fibrosis, and heart functional damage.

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Section: Discussionmentioning

confidence: 99%

Galectin-Receptor Interactions Regulates Cardiac Pathology Caused by Trichinella spiralis Infection

2021

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“…Additionally, we investigated correlations between FeNO and sRAGE biomarkers and asthma control measured by asthma control test (ACT). 24 Moreover, we evaluated the diagnostic value of FeNO and sRAGE to diagnose asthma or to aid in assessment of asthma control in children.…”

Section: Methodsmentioning

confidence: 99%

“…Serum sRAGE levels were negatively correlated to FeNO levels and low sRAGE was associated with wheezing children at high risk of asthma. 24 Interestingly, inhalation of steroids, decreased FeNO and increased sRAGE levels and improved asthma. 24 Another study highlighted an association of low serum sRAGE with acute and chronic morbidities of bronchiolitis including recurrent wheeze in hospitalized infants.…”

Section: Introductionmentioning

confidence: 99%

“… 24 Interestingly, inhalation of steroids, decreased FeNO and increased sRAGE levels and improved asthma. 24 Another study highlighted an association of low serum sRAGE with acute and chronic morbidities of bronchiolitis including recurrent wheeze in hospitalized infants. 25 Several reports investigated the pathophysiological mechanisms of RAGE axis, however, the variable expression of RAGE, the diversity of RAGE ligands, along with the overly complex nature of asthma disease, merit further research.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of Fraction of Exhaled Nitric Oxide and Soluble Receptor for Advanced Glycation End Products Biomarkers for Jordanian Asthmatic Children

Alzayadneh¹,

Bdour²,

Elayeh³

et al. 2023

JAA

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Purpose Fraction of exhaled nitric oxide (FeNO) and soluble advanced glycation end-product receptor (sRAGE) are proposed as biomarkers of asthma, therefore we sought to assess their use in asthmatic children of Jordan. Patients and Methods We conducted a case-control study at The University of Jordan Hospital. A total of 141 asthmatic children followed by respiratory pediatricians and 118 healthy children aged 4–18 years were recruited. FeNO was measured by NObreath device and serum sRAGE by ELISA that detect endogenously soluble isoform (esRAGE) and total soluble RAGE (sRAGE). Results sRAGE in asthmatic was half of the control (p <0.001). In addition, ratio of esRAGE/sRAGE was two-fold higher in asthmatic (p = <0.001). Neither FeNO nor esRAGE levels were significantly different between groups. FeNO and asthma control test (ACT) score were negatively correlated corrected for age and body mass index (BMI), (r = −0.180, p= 0.034). For the uncontrolled asthma group, esRAGE/sRAGE negatively correlated with ACT score (r = −.329, p = 0.038). Receiver operating curve (ROC) analysis revealed significant predictive value (PV) for sRAGE and esRAGE/sRAGE in asthma detection with area under the curve (AUC) of (0.751 ± 0.031) and (0.711±.033), consequently. However, no biomarker had a significant PV for lack of control. Conclusion The current study supports utilizing sRAGE as a marker for asthma and present a potential therapeutic target. However, our results indicate that both FeNO and sRAGE have a limited role in the management of asthmatic children or assessment of asthma control.

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“…eosinophilic airway inflammation. Tests can be performed with high repeatability and accuracy ( 22 – 24 ). Its main use is an adjunct to the diagnosis of TH2 type asthma and guiding the use of inhaled corticosteroid (ICS) treatment.…”

Section: Introductionmentioning

confidence: 99%

Lung Function in Preschool Children in Low and Middle Income Countries: An Under-Represented Potential Tool to Strengthen Child Health

Chaya

Zar²,

Gray³

2022

Front. Pediatr.

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BackgroundThe burden of respiratory disease is high in low-middle income countries (LMIC). Pulmonary function tests are useful as an objective measure of lung health and to track progression. Spirometry is the commonest test, but its use is limited in preschool children. Other lung function methods have been developed but their use in LMIC has not been well described.AimTo review the use of preschool lung function testing in children in LMIC, with particular reference to feasibility and clinical applications.MethodsElectronic databases “PubMed”, “Scopus”,” Web of Science”, and “EBSCO host” were searched for publications in low and middle income countries on preschool lung function testing, including spirometry, fractional exhaled nitric oxide (FeNO), oscillometry, interrupter technique, tidal breathing and multiple breath washout (MBW), from 1 January 2011 to 31 January 2022. Papers in English were included and those including only children ≥6 years were excluded.ResultA total of 61 papers from LMIC in Asia, South America, Africa, Eurasia or the Middle East were included. Of these, 40 included spirometry, 7 FeNO, 15 oscillometry, 2 interrupter technique, and 2 tidal breathing. The papers covered test feasibility (19/61), clinical application (46/61) or epidemiological studies (13/61). Lung function testing was successful in preschool children from LMIC. Spirometry was the most technically demanding and success gradually increased with age.ConclusionPreschool lung function testing is under-represented in LMIC for the burden of respiratory disease. These tests have the potential to strengthen respiratory care in LMIC, however access needs to be improved.

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Fraction of exhaled nitric oxide and soluble receptors for advanced glycation end products are negatively correlated in children with recurrent wheezing

Abstract: FeNO and sRAGE serum levels are negatively correlated in children with recurrent wheezing. Further larger scale studies are needed to test the use of FeNO and sRAGE as biomarkers for the prediction of asthma in children.

Cited by 14 publications

References 0 publications

Galectin-Receptor Interactions Regulates Cardiac Pathology Caused by Trichinella spiralis Infection

Galectin-Receptor Interactions Regulates Cardiac Pathology Caused by Trichinella spiralis Infection

Assessment of Fraction of Exhaled Nitric Oxide and Soluble Receptor for Advanced Glycation End Products Biomarkers for Jordanian Asthmatic Children

Lung Function in Preschool Children in Low and Middle Income Countries: An Under-Represented Potential Tool to Strengthen Child Health

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