2013
DOI: 10.18632/aging.100558
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Abstract: Phosphoinositol-3-kinase (PI3K) pathway is a crucial modulator of many physiological and pathophysiological phenomena, including aging, diabetes and cancer. Protein kinase Akt, a downstream effector of PI3K, controls a plethora of cellular functions, including gene transcription. A key mechanism connecting Akt activity to changes in gene expression is inhibitory phosphorylation of FOXO family of transcription factors. Accordingly, altered expression of FOXO targets may account for many biological consequences … Show more

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Cited by 17 publications
(43 citation statements)
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References 42 publications
(43 reference statements)
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“…Deregulated TFs can contribute to alterations in miRNA cluster expression and this is likely to be a widespread phenomenon (Yan et al, ). For example, regulation of chrX cluster (miR‐508/513a‐2, miR‐513b/513c) by forkhead box O1 (FOXO1) (Singhal et al, ). Binding of TFs to promoters can activate or repress transcription of miRNA clusters.…”
Section: Regulation Of Mirna Cluster Expressionmentioning
confidence: 99%
“…Deregulated TFs can contribute to alterations in miRNA cluster expression and this is likely to be a widespread phenomenon (Yan et al, ). For example, regulation of chrX cluster (miR‐508/513a‐2, miR‐513b/513c) by forkhead box O1 (FOXO1) (Singhal et al, ). Binding of TFs to promoters can activate or repress transcription of miRNA clusters.…”
Section: Regulation Of Mirna Cluster Expressionmentioning
confidence: 99%
“…Expression of these miRs is under direct control of the Akt-dependent FOXO1 and FOXO3 transcription factors. In turn, the miRs target these transcription factors as well as components of the PI3K and of MAPK cascade 132 .…”
Section: A) X Chromosomementioning
confidence: 99%
“…Also, the same study shows that inhibition of PI3K-AKT axis in LNCaP and MCF7 human carcinoma cell lines is followed by increased miR-506. As suggested by authors, miRNAs could be valuable biomarkers of FOXO activity 139 .…”
Section: Micrornas Functions Mediated By Foxosmentioning
confidence: 94%