Fox-Fordyce Disease in Male Identical Twins

Diseases of cutaneous appendages

“…1427,1428 There is intense pruritus which is sometimes intermittent. 1431,1432 Axillary lesions have occasionally resulted from the prolonged use of topical antiperspirants. 1431,1432 Axillary lesions have occasionally resulted from the prolonged use of topical antiperspirants.…”

Histopathology attributes of Fox–Fordyce disease

“…Ackerman 10,11 believed that a defect in infundibular keratinization was responsible for the inciting event. Others have questioned whether there is a genetically determined alternation of cornification as the existence of familiar cases has been documented 12 . A hormonal link to follicular plugging has been suggested 3 .…”

Fox-Fordyce Disease: Successful Treatment with Topical Clindamycin in Alcoholic Propylene Glycol Solution

“…Women are preferentially affected in an estimated sex ratio of 9/1. A few case reports of males with Fox-Fordyce disease have been published, including one of the original cases and another in male identical twins [2]. The majority of patients are between 13 and 35 years of age.…”