Fox-Fordyce disease. Control with tretinoin cream

Fox‐Fordyce Disease Exacerbated by Hyperhidrosis

“…Follicular plugging, secondary to hyperkeratosis, or chronic rubbing may result in hypohidrosis (2,3,10); Hypotrichosis is also described (4,10,11). Our patient, conversely, had hyperhidrosis that is atypical in FFD and normal axillary hair growth.…”

“…Excessive perspiration is reported as an exacerbating factor in FFD in the literature (11,12). This may theoretically suggest two forms of FFD: hyperhidrotic type and hypohidrotic type.…”

“…FFD was described in two sets of siblings, including male twins, suggesting a genetic component (3). In patients with FFD and hyperthyroidism, thyroidectomy may result in cure (11). Despite only a few reports, there may be an association with hidradenitis suppurativa (2).…”

“…The first reported case of FFD treated with tretinoin (0.1%) cream resulted in mild regression of papular lesions and marked reduction in itch. However, it also produced significant local irritation, controlled with 1% hydrocortisone cream (11). A latter study employed a 1:1 mixture of 0.05% tretinoin cream and 1% hydrocortisone cream, achieving complete resolution (10).…”

Fox-Fordyce Disease: Successful Treatment with Topical Clindamycin in Alcoholic Propylene Glycol Solution

“…Other therapeutics have also been tried with variable results such as topical corticosteroids, ultraviolet light [16], electrocoagulation [17] and surgical excision. More recently, topical tretinoin cream has been shown to reduce pruritus and restore hair growth at the affected sites [18].…”