Foveal avascular zone and foveal pit formation after preterm birth

Yanni, Susan E.; Wang, Jingyun; Chan, Melody; Carroll, Joseph; Farsiu, Sina; Leffler, Joel N.; Spencer, Rand; Birch, Eileen E.

doi:10.1136/bjophthalmol-2012-301612

Cited by 123 publications

(108 citation statements)

References 35 publications

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“…In addition, the study speculated that the retention of the inner retina might contribute to the abnormal foveal morphology in patients with a history of ROP. Several studies have reported a thick fovea in premature children and have associated it with early GA and/or low BW [5, 7, 8]. Similarly, our study demonstrated that the eyes in the ROP group had the greatest foveal thickness of all groups.…”

Section: Discussionsupporting

confidence: 71%

Foveal Depression and Related Factors in Patients with a History of Retinopathy of Prematurity

Miki¹,

Honda²,

Inoue³

et al. 2018

Ophthalmologica

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Purpose: This study evaluates optical coherence tomography (OCT) findings of the macula in patients with a history of retinopathy of prematurity (ROP). Methods: We enrolled 112 patients (age: 6–15 years) and categorized them into 3 groups: gestational age (GA) < 36 weeks with or without a history of ROP (ROP group, preterm group) and GA ≥37 weeks. We included 1 eye of each patient and measured the retinal thickness of the macula by OCT. Results: The ROP group demonstrated the worst VA and the shallowest foveal depression. Furthermore, foveal depression significantly correlated with birth weight, GA, ganglion cell layer/inner plexiform layer (GCL-IPL) thickness, and a history of ROP. Conclusions: This study established a correlation of fovea formation with premature birth, damage of GCL-IPL, and a history of ROP. The retention of the inner retina possibly contributes to abnormal foveal morphology in patients with a history of ROP.

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Section: Discussionsupporting

confidence: 71%

Foveal Depression and Related Factors in Patients with a History of Retinopathy of Prematurity

Miki¹,

Honda²,

Inoue³

et al. 2018

Ophthalmologica

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“…Our layer analysis of retinal SS-OCT images confirmed thicker central IRL and ONL+ layers in preterm children, as we and others have previously described [6, 30-32]. Significantly reduced BCVA showed a high correlation with a disproportion of the ONL+ and the IRL ( R = 0.824).…”

Section: Discussionsupporting

confidence: 63%

Choroidal Thickness with Swept-Source Optical Coherence Tomography versus Foveal Morphology in Young Children with a History of Prematurity

Bowl¹,

Bowl²,

Schweinfurth³

et al. 2018

Ophthalmic Res

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Aim: Comparison of choroidal thickness (CT) and foveal morphology as seen with swept-source optical coherence tomography (SS-OCT) in children with a history of treated or spontaneously regressed retinopathy of prematurity (tROP or srROP) to assess the impact on best-corrected visual acuity (BCVA). Methods: CT was measured by SS-OCT (DRI-OCT Triton; Topcon, USA) single scans of a 6-mm diameter around the fovea in 17 children with tROP or srROP (4–7 years of age) and compared to 25 controls (age-matched children and adults). The disproportion of the outer nuclear layer and inner retinal layers at the fovea (i.e., the ONL+/IRL ratio) as a measure of macular developmental arrest (MDA) was manually analyzed. BCVA was tested with ETDRS letter charts and correlated with the morphology. Results: CT was significantly thinner in children with tROP and srROP compared to term-born healthy children (nKids) at all measurement marks (p < 0.001), and mostly affected in the subfoveal area. tROP showed the lowest CT. CT allowed no direct conclusion about ONL+/IRL, but correlated positively with BCVA. Conclusions: Reduced CT in children with a history of ROP is linked to ROP severity. These findings overlap with the degree of MDA. CT appears to be involved in ROP, but MDA showed a higher impact on the BCVA of the examined cohort.

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“…[1][2][3][4][12][13][14] Electroretinography also suggests that central retinal dysfunction is greater than peripheral dysfunction. 5 OCT has revealed changes not evident on ophthalmoscopy, but these can be compatible with good visual acuity.…”

Section: Discussionmentioning

confidence: 99%

“…Studies have shown shallowing of the foveal depression, thickening of the central macula, and a continuity of inner retinal layers across the fovea in those born severely preterm, often despite normal macular appearance on ophthalmoscopy. [6][7][8][9][10][11][12][13][14] However, these macular changes evident on OCT are still compatible with good visual acuity. 6,7,[9][10][11] This has prompted authors to suggest that other factors might be contributory to the variation in vision seen in these patients.…”

Section: Introductionmentioning

confidence: 95%

Choroidal thickness in regressed retinopathy of prematurity

Anderson

Ramasamy

Lythgoe

et al. 2014

Eye

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Purpose To compare choroidal thickness in patients with regressed retinopathy of prematurity (ROP) with healthy controls using enhanced depth imaging optical coherence tomography (EDI OCT) Methods Twenty-four children and young adults (41 eyes) with regressed ROPZstage 3 had undergone EDI OCT with Spectralis FD-OCT as part of their clinical record. Their refraction, best-corrected visual acuity, and ophthalmoscopic findings were recorded. Corresponding data was collected prospectively from 33 healthy controls (58 eyes) who had been born at term. Choroidal thickness was measured independently by two observers subfoveally and at 1500 mm nasal and temporal to the fovea using EDI OCT. Results Mean subfoveal choroidal thickness, adjusted for refraction, was 271.1 mm (95% CI, 247.8-294.5) in the ex-ROP group, which was significantly thinner than 327.4 mm (95% CI, 293.8-360.9) in controls (P ¼ 0.008). Similarly, mean adjusted temporal choroidal thickness was 257.2 mm (95% CI, 240.2-274.2) in ex-ROP's vs 320.5 mm (95% CI, 288.6-352.3) in controls (P ¼ 0.001). There was no statistically significant difference in the nasal measurement. In the ex-ROP group, there was no significant correlation between subfoveal choroidal thickness and gestational age (r s ¼ 0.16, P ¼ 0.46) or birthweight (r s ¼ 0.03, P ¼ 0.90). In eyes without copathology in addition to regressed ROP (29 eyes, 19 patients), there was no significant correlation between subfoveal choroidal thickness and visual acuity. Conclusions Our findings of thinner subfoveal and temporal macular choroidal thickness in regressed ROP support the case for choroidal involvement in the pathogenesis of this condition.

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Foveal avascular zone and foveal pit formation after preterm birth

Cited by 123 publications

References 35 publications

Foveal Depression and Related Factors in Patients with a History of Retinopathy of Prematurity

Foveal Depression and Related Factors in Patients with a History of Retinopathy of Prematurity

Choroidal Thickness with Swept-Source Optical Coherence Tomography versus Foveal Morphology in Young Children with a History of Prematurity

Choroidal thickness in regressed retinopathy of prematurity

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