Four-year outcomes of hypofractionated high-dose-rate prostate brachytherapy and external beam radiotherapy

Long Term Results of High Dose Rate Brachytherapy and External Beam Radiotherapy for Local and Locally Advanced Prostate Cancer

“…In our series, as in others, patients who received adjuvant ADT had significantly higher risk features suggesting patient selection bias for CSS in this group of patients, instead of a negative interaction between HDR and EBRT [31][32].…”

“…All patients with Gleason score of 8 or higher had ADT for 1 year. They noted a 4-year actuarial CSS of 96.8% and of 100%, 100% and 94% for low, intermediate and high risk, respectively [32].…”

Within the next five years, most radiotherapy treatment schedules will be designed using spatiotemporal optimization

“…Nonetheless, numerous studies have already reported that the tumor BED calculated from treatment plans is positively correlated with clinical outcomes such as median survival and local control for many different sites, modalities, and fractionation schedules. 1, [16][17][18][19] BED models currently available may well be "at best a second order approximation to a complex patient-specific input-output relationship." However, Dr.…”