Four-week Negative Pressure Ventilation Improves Respiratory Function in Severe Hypercapnic COPD Patients

Gigliotti, Francesco; Spinelli, Andrea; Duranti, Roberto; Gorini, Massimo; Goti, P; Scano, Giorgio

doi:10.1378/chest.105.1.87

Cited by 22 publications

(21 citation statements)

References 26 publications

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“…Therefore, the increase in 6MWD was impressive as it had only been previously reported in uncontrolled trials [19,21,26]. RENSTON et al [27] found an increase in the 6MWD after 5 days of ventilation.…”

Section: Clinical Effects Of Noninvasive Mechanical Ventilationmentioning

confidence: 57%

“…RENSTON et al [27] found an increase in the 6MWD after 5 days of ventilation. Improvements in exercise capacity were also reported in other short- [19,21] and long-term studies [26]. In contrast, randomised controlled trials have failed to show a significant improvement in the 6MWD [5,[28][29][30][31].…”

Section: Clinical Effects Of Noninvasive Mechanical Ventilationmentioning

confidence: 58%

“…[20] after 7 days of ventilation and after 4 weeks by others [21,22]. Interestingly, GIGLIOTTI et al [21] measured the sequence of changes in Pa,CO 2 and VT after 13 and 27 days of ventilation and found that improvement was progressive.…”

Section: Physiologial Effects Of Noninvasive Mechanical Ventilationmentioning

confidence: 99%

“…Interestingly, GIGLIOTTI et al [21] measured the sequence of changes in Pa,CO 2 and VT after 13 and 27 days of ventilation and found that improvement was progressive. All of the above studies have concluded that beneficial effects of NIMV can be attributed to the improvement in inspiratory muscle function, particularly because the rest achieved during ventilation sessions could alleviate a possible ''chronic fatigue'' of the Borg scale points NIMV 6.6¡1.…”

Section: Physiologial Effects Of Noninvasive Mechanical Ventilationmentioning

confidence: 99%

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Physiological and clinical effects of diurnal noninvasive ventilation in hypercapnic COPD

Díaz¹

2005

European Respiratory Journal

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To assess the clinical impact of noninvasive mechanical ventilation (NIMV) on stable hypercapnic chronic obstructive pulmonary disease, changes in exercise capacity, dyspnoea and simple physiological parameters were evaluated. The time course of these effects during treatment and recovery was also assessed.Patients were randomly allocated to NIMV (n527) or sham-NIMV (n515), applied 3 h?day -1 , 5 days a week, for 3 weeks. A 6-min walking distance (6MWD), arterial blood gases, spirometry, pattern of breathing, mouth occlusion pressure (P0.1), and respiratory system impedance (P0.1/ tidal volume (VT)/inspiratory time (tI)) were measured weekly during treatment and 2 weekly during follow-up. Transition dyspnoea index (TDI) was also measured. During NIMV, carbon dioxide arterial tension decreased progressively, concomitantly with a slow deep pattern of breathing, a proportional increase in the forced expiratory volume in one second (FEV1), the forced vital capacity and significant reductions of P0.1 and P0.1/VT/tI. The 6MWD improved by a mean of 76 m after NIMV, and by 73 m and 61 m 1 and 2 weeks, respectively, after treatment. Dyspnoea improved with a mean TDI of three points. Changes in 6MWD were highly related to TDI and to a lesser extent to changes in FEV1 (r50.60).The current authors conclude that noninvasive mechanical ventilation has significant and sustained clinical impact in stable hypercapnic chronic obstructive pulmonary disease.

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Section: Clinical Effects Of Noninvasive Mechanical Ventilationmentioning

confidence: 57%

Section: Clinical Effects Of Noninvasive Mechanical Ventilationmentioning

confidence: 58%

Section: Physiologial Effects Of Noninvasive Mechanical Ventilationmentioning

confidence: 99%

Section: Physiologial Effects Of Noninvasive Mechanical Ventilationmentioning

confidence: 99%

See 2 more Smart Citations

Physiological and clinical effects of diurnal noninvasive ventilation in hypercapnic COPD

Díaz¹

2005

European Respiratory Journal

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“…Not surprisingly, the EMG activity of the diaphragm was reduced only after familiarization with the ventilator [31,32]. More recently, GIGLIOTTI and co-workers [33,34] studied the effects of NPV on EMG activity of the diaphragm and parasternal muscles in normal subjects [33] and in COPD patients [34]. In these studies, in which respiratory frequency, t I, and t E were adjusted to approximate the subject's spontaneous timing components, NPV resulted in a substantial suppression of EMG activity of the inspiratory muscles [33][34].…”

Section: Respiratory Musclesmentioning

confidence: 97%

Negative pressure ventilation in the treatment of acute respiratory failure: an old noninvasive technique reconsidered

Corrado¹,

Gorini²,

Villella³

et al. 1996

European Respiratory Journal

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Negative pressure ventilation in the treatment of acute respiratory failure: an old noninvasive technique reconsidered. A. Corrado, M. Gorini, G. Villella, E. De Paola. ©ERS Journals Ltd 1996. ABSTRACT: Noninvasive mechanical ventilatory techniques include the use of negative and positive pressure ventilators. Negative pressure ventilators, such as the "iron lung", support ventilation by exposing the surface of the chest wall to subatmospheric pressure during inspiration; whereas, expiration occurs when the pressure around the chest wall increases and becomes atmospheric or greater than atmospheric.In this review, after a description of the more advanced models of tank ventilators and the physiological effects of negative pressure ventilation (NPV), we summarize the recent application of this old technique in the treatment of acute respiratory failure (ARF). Several uncontrolled studies suggest that NPV may have a potential therapeutic role in the treatment of acute on chronic respiratory failure in patients with chronic obstructive pulmonary disease and restrictive thoracic disorders, reducing the need for endotracheal intubation. In the paediatric field, after substantial technical improvement, NPV has been successfully reintroduced for the treatment of ARF due to neonatal distress syndrome and bronchopulmonary dysplasia, and for the weaning from positive pressure ventilation in intubated patients.The positive results of these reports need to be formally confirmed by further prospective and controlled studies before recommending the generalized use of negative pressure ventilation in acute respiratory failure as a standard of care.

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Negative Noninvasive Mechanical Ventilation: External Negative Pressure Ventilation (ENPV)

Mollica,

Vincenzi

2023

Noninvasive Mechanical Ventilation

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Four-week Negative Pressure Ventilation Improves Respiratory Function in Severe Hypercapnic COPD Patients

Cited by 22 publications

References 26 publications

Physiological and clinical effects of diurnal noninvasive ventilation in hypercapnic COPD

Physiological and clinical effects of diurnal noninvasive ventilation in hypercapnic COPD

Negative pressure ventilation in the treatment of acute respiratory failure: an old noninvasive technique reconsidered

Negative Noninvasive Mechanical Ventilation: External Negative Pressure Ventilation (ENPV)

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