Four-Eyelid Sebaceous Cell Carcinoma Following Irradiation

Abstract

Background: Sebaceous cell carcinoma is a distinctive tumor of the eyelid associated with a high rate of metastasis and mortality. Involvement of both upper and lower lids has been described; however, involvement of all 4 eyelids is extremely rare. Objective: To describe the evaluation and diagnosis of the clinicopathologic features in a 74-year-old patient with 4-eyelid sebaceous carcinoma and a history of whole face irradiation for eczema. Methods: Bilateral eyelid, conjunctiva, map, and fine needle biopsy of enlarged, submandibular lymph node specimens were stained with hematoxylin-eosin and oilred-O for light microscopy and fresh-frozen sections were evaluated by electron microscopy. Results: The biopsy specimens from the eyelids and conjunctiva showed sebaceous carcinoma cells in the meibomian glands and scattered within the conjunctival epithelium. The cells were moderately well differentiated. Similar cells stained with oil-redO were found in the submandibular lymph nodes.

Sebaceous Carcinoma of the Eyelid: Proposed Nomenclature for Multifocal and Multicentric Disease

“…An additional patient from authors LAD and AAT was added for a total of 15 clinical presentations (Table ). 8,[11][12][13][18][19][20][21][22] There were 12 females (80%), and 3 males (20%). The average age at diagnosis was 72 years, and average time to diagnosis was 18 months.…”

Sebaceous Carcinoma of the Eyelid: Proposed Nomenclature for Multifocal and Multicentric Disease

“…An additional patient from authors LAD and AAT was added for a total of 15 clinical presentations (Table ). 8,[11][12][13][18][19][20][21][22] There were 12 females (80%), and 3 males (20%). The average age at diagnosis was 72 years, and average time to diagnosis was 18 months.…”

External auditory canal sebaceous carcinoma

“…The first report of radiation-induced SC was suggested as a possible risk factor was in 1970 by Martin et al 19. Multiple reports of SC in areas in which radiation was used to treat other conditions was previously reported 20 21. Interestingly, diuretic use was also reported as a possible risk factor 22.…”

Ocular sebaceous carcinoma: Case report and review of the literature

“…9 Exposure to external beam radiation has been linked to several cases of sebaceous carcinoma occurring in young patients and those with multiple eyelid involvement. 9 Ocular sebaceous carcinoma is usually an indolent, locally aggressive tumor, but it can metastasize to regional lymph nodes and even distant sites such as the brain, lungs, liver, bone and colon (Torre syndrome). 10 In one series there was a 28% incidence of metastasis.…”

Sebaceous Carcinoma of the Eyelid: Proposed Nomenclature for Multifocal and Multicentric Disease

“…An additional patient from authors LAD and AAT was added for a total of 15 clinical presentations (Table ). 8,[11][12][13][18][19][20][21][22] There were 12 females (80%), and 3 males (20%). The average age at diagnosis was 72 years, and average time to diagnosis was 18 months.…”

External auditory canal sebaceous carcinoma

“…The first report of radiation-induced SC was suggested as a possible risk factor was in 1970 by Martin et al 19. Multiple reports of SC in areas in which radiation was used to treat other conditions was previously reported 20 21. Interestingly, diuretic use was also reported as a possible risk factor 22.…”

Ocular sebaceous carcinoma: Case report and review of the literature

“…9 Exposure to external beam radiation has been linked to several cases of sebaceous carcinoma occurring in young patients and those with multiple eyelid involvement. 9 Ocular sebaceous carcinoma is usually an indolent, locally aggressive tumor, but it can metastasize to regional lymph nodes and even distant sites such as the brain, lungs, liver, bone and colon (Torre syndrome). 10 In one series there was a 28% incidence of metastasis.…”

Sebaceous Carcinoma of the Eyelid: Proposed Nomenclature for Multifocal and Multicentric Disease

“…An additional patient from authors LAD and AAT was added for a total of 15 clinical presentations (Table ). 8,[11][12][13][18][19][20][21][22] There were 12 females (80%), and 3 males (20%). The average age at diagnosis was 72 years, and average time to diagnosis was 18 months.…”

External auditory canal sebaceous carcinoma

“…The first report of radiation-induced SC was suggested as a possible risk factor was in 1970 by Martin et al 19. Multiple reports of SC in areas in which radiation was used to treat other conditions was previously reported 20 21. Interestingly, diuretic use was also reported as a possible risk factor 22.…”

Ocular sebaceous carcinoma: Case report and review of the literature

“…9 Exposure to external beam radiation has been linked to several cases of sebaceous carcinoma occurring in young patients and those with multiple eyelid involvement. 9 Ocular sebaceous carcinoma is usually an indolent, locally aggressive tumor, but it can metastasize to regional lymph nodes and even distant sites such as the brain, lungs, liver, bone and colon (Torre syndrome). 10 In one series there was a 28% incidence of metastasis.…”