“…Each of the methods to validate the accuracy of image registration described in the literature (Balter and , Brock et al 2005, Coselmon et al 2004, Rietzel and Chen 2006, Heath et al 2007, Wijesooriya et al 2008, Kessler 2006, Wang et al 2005, Schnabel et al 2003, Kybic and Unser 2003, Kashani et al 2007, Zhong et al 2007, Liu et al 2012, Hardcastle et al 2012, Szegedi et al 2012and Szegedi et al 2013, Latifi et al 2013, Du et al 2012, Schreibmann et al 2012, Bender and Tome 2009, Varadhan et al 2013, Mencarelli et al 2012, Paganelli et al 2013 has its drawbacks. Visible landmarks may consist of voxels that actually drive the registration and hence the geometric accuracy of the registration in homogeneous regions may differ from the accuracy measured in the landmarks.…”