Four children with colchicine poisoning

Ataş, Bülent; Çaksen, Hüseyîn; Tuncer, Oğuz; Kırımi, Ercan; Akgün, Cihangir; Odabaş, Dursun

doi:10.1191/0960327104ht457sc

Cited by 30 publications

(12 citation statements)

References 7 publications

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“…Findings from our study provide strong evidence suggesting that extracellular histones promote regression of hair follicles. Our data, together with data on colchicine-induced hair loss (16,17) and colchicine-driven H4 expression in DP cells (10), provide strong evidence suggesting Following culture of isolated human hair follicles (HFs) in the absence or presence of 20 lg/ml histone H4 and H2A (New England Biolabs, Beverly, MA) for 6 days, gross pictures were taken (a-c). Hair shaft elongation was also measured in the presence of 20 lg/ml concentrations of histone H4 and H2A after cultivation for 6 days (h).…”

Section: Resultsmentioning

confidence: 53%

Extracellular histones inhibit hair shaft elongation in cultured human hair follicles and promote regression of hair follicles in mice

Shin

Joo

Kim

et al. 2012

Experimental Dermatology

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Release of histone H4 in rat vibrissa dermal papilla (DP) cells exposed to sub-toxic dose of colchicines has been recently reported. In addition, exposure to histone H4 has been reported to result in inhibited proliferation and reduced alkaline phosphatase (ALP) activity of cultured vibrissa DP cells. These findings prompted us to investigate the role of extracellular histones in hair growth using cultured human hair follicles and hair cycling using back skin of mice. We report here that exposure of cultured hair follicles to histone H4 and H2A resulted in significant inhibition of elongation of hair shafts, decreased expression of IGF-1 and decreased expression and activity of ALP. Injection of histones into hypodermis of mice during anagen resulted in premature onset of catagen. Findings of the current study provide strong evidence suggesting the inhibitory role of extracellular histones in hair growth.

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Section: Resultsmentioning

confidence: 53%

Extracellular histones inhibit hair shaft elongation in cultured human hair follicles and promote regression of hair follicles in mice

Shin

Joo

Kim

et al. 2012

Experimental Dermatology

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“…Given that colchicine is the mainstay of treatment in FMF, one may wonder if it can contribute to the liver abnormalities observed in FMF patients. Although hepatotoxicity can occur with colchicine intoxication, doses superior to 5 mg per day, much higher than doses used to treat FMF, are required 69,70 . At the pathophysiological level, animal models have shown that intraperitoneal administration of high doses of colchicine affects Kupffer cell function, leading to reduced toxin clearance 71 .…”

Section: Discussionmentioning

confidence: 99%

Non‐amyloid liver involvement in familial Mediterranean fever: A systematic literature review

Fraisse

Savey

Hentgen

et al. 2020

Liver International

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Introduction: Familial Mediterranean fever (FMF), the most frequent autoinflammatory disease, is caused by mutations in the MEFV gene. It is characterized by recurrent febrile attacks of polyserositis. Liver abnormalities may develop during its course, but they remain poorly defined.Objective: To describe liver involvement in FMF patients. Methods:A systematic search was conducted through PubMed/Medline and Embase from 1946 to January 2020. All articles describing children and adults with FMF and liver involvement were included. Patients with amyloidosis were excluded. The selected full-text articles were independently reviewed by three investigators.Results: Forty-three articles were identified, of which 20 articles with a total of 99 patients were included: 74 adults, 23 children and two patients of unknown age. Ten patients had cryptogenic cirrhosis, 48 had nonalcoholic fatty liver disease (NAFLD), four had Budd-Chiari syndrome (BCS), 12 had isolated hyperbilirubinaemia and 25 had elevated liver enzymes. Conclusion:Despite a low prevalence of metabolic risk factors, FMF may be associated with NAFLD and cryptogenic cirrhosis as a consequence of chronic or recurrent inflammation. FMF patients should be regularly screened for liver injury. The latter may be prevented and treated by daily colchicine intake. The evidence was insufficient to establish an association with BCS, hyperbilirubinaemia or autoimmune hepatitis. K E Y W O R D Scolchicine, cytolysis, familial Mediterranean fever, inflammation, nonalcoholic fatty liver disease, nonalcoholic steatohepatitis

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“…Crocenzi et al6 demonstrated that in experimental models, colchicine-induced hepatotoxicity depended on the magnitude and composition of the bile salt flux traversing the liver. Ataş et al7 reported the cases of four children who presented with gastrointestinal symptoms, hepatotoxicity, cardiotoxicity and bone marrow suppression after colchicine poisoning. However, no cases of hepatotoxicity resulting from therapeutic doses of either thiocolchicoside or colchicine have been reported.…”

Section: Discussionmentioning

confidence: 99%