Formulation of Polyherbomineral Matrices for Treatment of Osteoporosis

Mulchand, Shende; Seema, Mendhekar

doi:10.22159/ajpcr.2017.v11i1.21777

Cited by 5 publications

(5 citation statements)

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“…Phytoestrogenic steroids present in it have been shown to influence early regeneration and quick mineralization of bone fracture healing process 37 . Terminalia arjuna and Acacia arabica are used for their fracture healing potential 38,39 . Emblica officinalis is another herb that is reported to effectively reduce bone loss and increase bone strength in the experimental model of osteoporosis 40 .…”

Section: Effect On Architecture Of Femur Bonementioning

confidence: 99%

Untitled

2021

IJPSR

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Osteoporosis is a condition that makes the bones porous, fragile, and prone to fractures. Although it is very prevalent in elderly people, it is more common in women, especially after menopause. The present study aimed to evaluate the effect of Asthiposhak tablets on their anti-osteoporotic activity in ovariectomized (OVX) rats. Thirty-two female albino Wistar rats were randomly divided into four groups (n=8). Group 1 served as sham-operated control. Group 2 rats were ovariectomized (OVX) and served as a negative control. Group 3 received raloxifene (5.4 mg/kg i.p.) and served as the standard control, and Group 4 received Asthiposhak (405 mg/kg p.o.) and served as treatment control. 60 days after ovariectomizing, animals were treated with Asthiposhak for the next 45 days. At the end of the study, femur bone length, weight, bone ash calcium level, and bone mineral density (BMD) were estimated. The levels of serum alkaline phosphatase (ALP), calcium, and phosphorous, and bone histopathology were also evaluated. OVX-induced increased serum ALP, calcium, and phosphorous levels were significantly attenuated in Asthiposhaktreated rats. Asthiposhak treatment significantly prevented an OVX-induced increase in body weight. The calcium content in bone ash was significantly increased on Asthiposhak treatment indicating remineralization of bones. OVXinduced decrease in BMD was significantly reversed in Asthiposhak-treated animals. Femur bone histopathology revealed increased trabecular thickness and decreased osteoclast formation in Asthiposhak-treated animals. Asthiposhak exhibited a significant anti-osteoporotic effect in the experimental model of OVX-induced osteoporosis in rats. These results indicate Asthiposhak can be beneficial in postmenopausal osteoporosis.

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Section: Effect On Architecture Of Femur Bonementioning

confidence: 99%

Untitled

2021

IJPSR

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“…Tab HF-B1 is a proprietary Ayurvedic formulation which helps in improving the metabolism of Asthi dhatu. 9,10…”

Section: About the Formulation And Its Ingredientsmentioning

confidence: 99%

Clinical Evaluation of Efficacy and Safety of Tab Hf-B1 in Osteopenia and Osteoporosis: An Observational Study

Omkar¹,

Deo²,

Shrikhande³

2019

Int. J. Res. Ayurveda Pharm.

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Osteopenia and Osteoporosis has been a very common problem faced globally on account of faulty lifestyle, diet and environmental reasons. It increases chances of debility due to frequent fractures and inflammatory conditions. Conventional medications contain synthetic calcium supplementation which mostly remains a temporary solution with potential gastrointestinal and cardiovascular side effects. This calls for the need to explore effective treatment modalities. Herbal medicines have proved efficacious in the treatment of bone disorders since ancient time. Herewith we studied Tab HF-B1, a herbomineral Ayurvedic formulation for the treatment of osteopenia and osteoporosis in an open label, observational clinical study. We observed that there was decrease in mean ranks of symptoms such as bone pain and joint pain. There was a significant increase in T-Score and BQI. No adverse events were recorded suggesting a good compliance and tolerability. Thus Tab HF-B1 was found to be safe and effective in the management of patients with Osteopenia and Osteoporosis.

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“…Firstly, the research was often questioned and contested. For example, in Singapore, the then-Minister of Manpower who was interviewed on the BBC argued that the Human Rights Watch report misrepresented and exaggerated the extent of "maid abuse" in Singapore, and that the standards of research were flawed (Mulchand, 2005). These debates about the credibility of research were perhaps the most intense in South Africa.…”

Section: The Role Of Researchmentioning

confidence: 99%

How Unpopular Policies are Made: Examples from South Africa, Singapore and Bangladesh

Palmary

Gruchy

Ashraf

et al. 2018

International Migration

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In this article we contribute to the emerging knowledge on migration policy‐making in two ways. Firstly, we address the relative lack of research on the gendered nature of migration policy‐making. Secondly we contribute to understanding migration policymaking in postcolonial contexts. Based on case studies from Bangladesh, South Africa, and Singapore, we trace the drivers of policy change in these contexts and how the gendered vulnerability of the intended beneficiaries impacted the policy process. We found that there were four main drivers of migration policy‐making in each of the countries. They were: the role‐players in the policy change process, the debates that shaped the policy change, the research involved, and the political context in which the policy change took place. While our research drew on existing policy frameworks, it also showed that policy development is shaped by complex socio‐political conditions.

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Formulation of Polyherbomineral Matrices for Treatment of Osteoporosis

Cited by 5 publications

References 0 publications

Untitled

Untitled

Clinical Evaluation of Efficacy and Safety of Tab Hf-B1 in Osteopenia and Osteoporosis: An Observational Study

How Unpopular Policies are Made: Examples from South Africa, Singapore and Bangladesh

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