A design strategy for optimal design of composite grid-stiffened panels subjected to global and local buckling constraints is developed using a discrete optimizer. An improved smeared stiffener theory is used for the global buckling analysis. Local buckling of skin segments is assessed using a Rayleigh Ritz method that accounts for material anisotropy and transverse shear exibility. The local buckling of stiffener segments is also assessed. Design variables are the axial and transverse stiffener spacing, stiffener height and thickness, skin laminate, and stiffening con guration, where the stiffening con guration is herein de ned as a design variable that indicates the combination of axial, transverse, and diagonal stiffeners in the stiffened panel. The design optimization process is adapted to identify the lightest-weight stiffening con guration and stiffener spacing for grid-stiffened composite panels given the overall panel dimensions, in-plane design loads, material properties, and boundary conditions of the grid-stiffened panel. Nomenclature a, b = axial and transverse stiffener spacing, respectively F (X, r i ) = modi ed objective function h = stiffener height ICON = design variable for stiffening con guration i = generation or iteration cycle in the optimization procedure LAMI = design variable for stacking sequence of skin laminate M = population size N c = number of design constraints N d = number of design variables Q = normalizing constant r i = penalty parameter [ u g j (X )u 1 g j (X )] 2 N c r ( i j = penalty function t = skin laminate thickness t s = stiffener thickness W (X ) = weight of panel per unit area w s