Formulation and optimization of albumin nanoparticles loaded ivabradine hydrochloride using response surface design

Jenita, J. Josephine Leno; Tibrewal, Richa; Rathore, Seema S.; Manjula, D.; Wilson, Barnabas; Mahesh, Agasa Ramu

doi:10.1016/j.jddst.2021.102461

Cited by 6 publications

(4 citation statements)

References 22 publications

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“…Similar findings have been reported in literature and this may be due to the mechanical impact the speed can produce once the lipospheres are formed. 26 Entrapment of the drug in the lipid matrix is bound to depend on the composition of the lipospheres. It was found that the concentration of cholesterol was more important for entrapment than the triglyceride followed by speed.…”

Section: Discussionmentioning

confidence: 99%

The Amalgamation of Risk Assessment Using Quality by Design Principles and Prediction of Regression Models in the Development of Dexmedetomidine-loaded Lipospheres for Intra-articular Administration

Gorajiya¹,

Lalwani²

2023

J. Young Pharm.

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Background: Dexmedetomidine is a promising candidate for pain relief and is being evaluated as an alternative or adjuvant to other treatment modalities. The intraarticular administration of such drugs is expected to give localised effect and the release of drug from drug delivery systems can be programmed to lengthen the duration of action. Purpose: The aim of the present investigation was to develop dispersion of lipospheres for the Dexmedetomidine for intraarticular administration that releases drug over a period of one week. Materials and Methods: DEX-LPS were formulated using the multiple emulsion technique. The particle size of lipospheres, drug entrapment, and percentage of drug release qualified as critical quality attributes. Risk assessment was done for the material attributes and process parameters based on the quality by design principles. The amount of cholesterol, triglyceride and the speed of homogenization during the primary emulsion formulation were identified as critical variables and therefore studied systematically using a Box-Behnken Design. Mathematical models generated for each critical quality attribute and their relationship with predictors was explored, using RStudio, to get a product that had the largest particle size, highest entrapment and desirable drug release profile. Results: Overlay plots were generated and the formulation at the center point settings had the required desirability. The acceptance range for the in-process and end-product quality attributes was established and tested in the product. The product remained stable at 2-8°C during 6 months of study. Conclusion: Stable DEX-LPS that could sustain drug release for 7 days was developed.

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Section: Discussionmentioning

confidence: 99%

The Amalgamation of Risk Assessment Using Quality by Design Principles and Prediction of Regression Models in the Development of Dexmedetomidine-loaded Lipospheres for Intra-articular Administration

Gorajiya¹,

Lalwani²

2023

J. Young Pharm.

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“…To study interactions between the drug and polymers, FT-IR studies between capecitabine and the excipients were recorded by KBr disks. Peaks of the pure drug and its combination with the polymer were obtained, and their compatibility was observed by studying various frequencies of the vibration modes 20 .…”

Section: Ft-ir Spectroscopymentioning

confidence: 99%

“…The morphology and the structure of NPs were observed and recorded using transmission electron microscopy (JEM 1230 electron microscope Jeol, Tokyo, Japan). A drop of diluted samples (GG-EC-CAPC NPs) was used on a copper-coated carbon grid and allowed to dry for about 15 min 20 . A lter paper removed excess dispersion and left the grid to air-dry.…”

Section: Determination Of Surface Morphologymentioning

confidence: 99%

Guar Gum and Ethyl Cellulose Nanoparticles Encapsulating Capecitabine for the Management of Colorectal Cancer: Formulation and Assessment

Pasupathy,

Rathore,

et al. 2024

Preprint

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Currently, most nanotechnology-mediated drug delivery systems are targeted towards cancer therapy. The guar gum and ethyl cellulose nanoparticle-based delivery system developed in this study demonstrates the potential of nanotechnology-mediated approaches for the targeted and sustained delivery of capecitabine in managing colorectal cancer. Guar gum and Ethyl cellulose have been selected as polymers to formulate nanoparticles for colon targeting. Different batches of drug-loaded GG-EC nanoparticles were prepared by the emulsion solvent diffusion method. The optimal batch exhibited a particle dimension of 235.6 ± 4.28 nm with a polydispersity index (PDI) of 0.153 and a zeta potential of -23.4 ± 3.12 millivolts. The in vitro drug release pattern demonstrated that the liberation of capecitabine was sustained for 24 hours. The mechanism of drug release from formulated nanoparticles was followed with Non-Fickian mediated with diffusion-controlled. Animal studies determined the targeting efficiency of the ideal formulation. Results indicated that the concentration of capecitabine was higher than the standard drug. The distinctive characteristics of the polymers employed in the nanoparticle formulation facilitate specific drug discharge in the colon, diminishing systemic contact and amplifying remedial effectiveness.

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“…The preparation of carnosic acid-loaded albumin nanoparticles was carried out according to the previous report [25]. Typically, 100 mg of BSA was dissolved in 10 mL of deionized water containing 10 mg of carnosic acid.…”

Section: Preparation Of Nanoparticles 221 Synthesis Of Ca-loaded Albu...mentioning

confidence: 99%

Carnosic Acid Encapsulated in Albumin Nanoparticles Induces Apoptosis in Breast and Colorectal Cancer Cells

et al. 2022

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Carnosic acid (CA) is a natural phenolic compound with several biomedical actions. This work was performed to study the use of CA-loaded polymeric nanoparticles to improve the antitumor activity of breast cancer cells (MCF-7) and colon cancer cells (Caco-2). CA was encapsulated in bovine serum albumin (BSA), chitosan (CH), and cellulose (CL) nanoparticles. The CA-loaded BSA nanoparticles (CA-BSA-NPs) revealed the most promising formula as it showed good loading capacity and the best release rate profile as the drug reached 80% after 10 h. The physicochemical characterization of the CA-BSA-NPs and empty carrier (BSA-NPs) was performed by the particle size distribution analysis, transmission electron microscopy (TEM), and zeta potential. The antitumor activity of the CA-BSA-NPs was evaluated by measuring cell viability, apoptosis rate, and gene expression of GCLC, COX-2, and BCL-2 in MCF-7 and Caco-2. The cytotoxicity assay (MTT) showed elevated antitumor activity of CA-BSA-NPs against MCF-7 and Caco-2 compared to free CA and BSA-NPs. Moreover, apoptosis test data showed an arrest of the Caco-2 cells at G2/M (10.84%) and the MCF-7 cells at G2/M (4.73%) in the CA-BSA-NPs treatment. RT-PCR-based gene expression analysis showed an upregulation of the GCLC gene and downregulation of the BCL-2 and COX-2 genes in cells treated with CA-BSA-NPs compared to untreated cells. In conclusion, CA-BSA-NPs has been introduced as a promising formula for treating breast and colorectal cancer.

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Formulation and optimization of albumin nanoparticles loaded ivabradine hydrochloride using response surface design

Cited by 6 publications

References 22 publications

The Amalgamation of Risk Assessment Using Quality by Design Principles and Prediction of Regression Models in the Development of Dexmedetomidine-loaded Lipospheres for Intra-articular Administration

The Amalgamation of Risk Assessment Using Quality by Design Principles and Prediction of Regression Models in the Development of Dexmedetomidine-loaded Lipospheres for Intra-articular Administration

Guar Gum and Ethyl Cellulose Nanoparticles Encapsulating Capecitabine for the Management of Colorectal Cancer: Formulation and Assessment

Carnosic Acid Encapsulated in Albumin Nanoparticles Induces Apoptosis in Breast and Colorectal Cancer Cells

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