Formulation and Investigation of CK2 Inhibitor-Loaded Alginate Microbeads with Different Excipients
Boglárka Papp,
Marc Le Borgne,
Florent Perret
et al.
Abstract:The aim of this study was to formulate and characterize CK2 inhibitor-loaded alginate microbeads via the polymerization method. Different excipients were used in the formulation to improve the penetration of an active agent and to stabilize our preparations. Transcutol® HP was added to the drug–sodium alginate mixture and polyvinylpyrrolidone (PVP) was added to the hardening solution, alone and in combination. To characterize the formulations, mean particle size, scanning electron microscopy analysis, encapsul… Show more
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