Formulation and Evalution of Oral Reconstitutable Suspension of Cefpodoxime Proxetil

Gc, Patel; Prajapati, Jagruti B.; Km, Morthana; Khunt, Dignesh

doi:10.15744/2348-9782.2.101

Cited by 2 publications

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References 4 publications

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“…The withdrawal samples were replaced by an equal amount of dissolution medium to maintain constant volume during the study. UV Spectrophotometry analyzed samples for determination of Beta-sitosterol content using calibration curve equation data 13 .…”

Section: Evaluation Of Reconstitution Of Dry Suspensionmentioning

confidence: 99%

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2023

IJPSR

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Introduction: Herbs, which have been used to cure numerous ailments since ancient times, are important in building the foundation of modern medications. They are relatively safe to use, easily available, and also affordable. The present study aimed to investigate dry powder suspension formulated with Linum usitatissimum seeds extract, Cucurbita pepo seeds extract, Sesamum indicum seeds extract and Helianthus annuus seeds extract. Method and Material: The Soxhlet apparatus prepared Plant extracts using ethanol as a solvent. Various batches were prepared using the dried seed extract of individual herbs and the excipients. Further evaluation studies were carried out for all the batches to finalize the optimized batch showing good flow properties and drug release profile. Results: The optimized formulations showed acceptable evaluation results, including pH, angle of repose, carr's index, sedimentation volume, redispersibility, viscosity, and drug release. Conclusion:The formulated dry powder suspension formulations showed good evaluation results and were within limits. INTRODUCTION:Linum usitatissimum (Flax seed): Flaxseed Fig. 1 is an annual herb member of the Linaceae family. The flax plant thrives in deep moist soils rich in sand, silt, and clay. The specie is native to the region extending from the eastern Mediterranean through Western Asia and the Middle East to India. The two basic varieties of flax seeds are brown and yellow or golden in colour 1 . It is cultivated on over 2.6 million hectares and the important linseedgrowing countries are India, Canada, China, the United States, and Ethiopia 2, 3 .

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Section: Evaluation Of Reconstitution Of Dry Suspensionmentioning

confidence: 99%

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2023

IJPSR

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Development and in-vitro Evaluation of Reconstitutable Suspension of Flucloxacillin

2016

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The objective of present study was to develop a stable reconstitutable suspension of Flucloxacillin magnesium using xanthan gum as suspending agent. The powder blend was evaluated for its flow properties and F3, F4 showed acceptable flow properties but remaining formulations were failed to show acceptable flow properties. There were no interactions between the drug and excipients used in the suspension which was confirmed from the compatibility studies. Reconstitutable suspension was evaluated for its color, taste, viscosity, ph, sedimentation volume, deliverable volume, density, resuspendability, drug content, drug release and stability. Formulation F3 showed maximum drug release of 97.03% in 45 min. in evaluating period of 14 days, there were no significant changes observed in viscosity, ph, drug content and rug release rate. From the obtained results, it could be concluded that the effective reconstitutable suspension of Flucloxacillin magnesium was achieved and successfully evaluated in the form of reconstitutable suspension.

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Formulation and Evalution of Oral Reconstitutable Suspension of Cefpodoxime Proxetil

Cited by 2 publications

References 4 publications

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Development and in-vitro Evaluation of Reconstitutable Suspension of Flucloxacillin

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