Formulation and Evaluation of Timolol Maleate Proniosomal Gel for Ocular Drug Delivery

Abstract

Each chemical utilised were of the highest quality. Methodspre-formulation studies determination of solubility of timolol maleate By using the shake flask method, the solubility of Timolol maleate in aqua, ethyl alcohol, PBS pH 6.8, PBS pH 7.4, and ether was measured. In a flask containing 10 ml of each solvent, an excess amount of the medication was introduced. The mixtures were then agitated at 100 rpm for 24 hours inside a thermostatically managed water bath at 370.5°C, filtered, diluted, and spectrophotometrically assessed at 294.4 nm using a UV spectrophotometer against a blank that had been treated similarly. 5 Standard curve for timolol maleateThe medication (10 mg) was precisely weighed and put within a 100 mL measuring flask. To make this stock solution-I, the drug was dissolved in 7.4 pH buffer solution and diluted until 10 mL with the similar