Formulation and evaluation of natural gum-based sustained release matrix tablets of flurbiprofen using response surface methodology

Shah, Syed Nisar Hussain; Asghar, Sajid; Choudhry, M.A.; Akash, Muhammad Sajid Hamid; Rehman, Nadia; Baksh, Sattar

doi:10.3109/03639040903025848

Cited by 41 publications

(17 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…stretching, respectively. These FTIR studies are found to be in line with previous studies, suggesting that there was drug stability during the direct compression technique (Shah et al, 2009). …”

Section: Fourier Transform Infrared Spectroscopysupporting

confidence: 91%

“…A CCD with α = 1.414 was employed as per the standard protocol (Shah et al, 2009;Singh et al, 2005c). The amounts of CP (X 1 ) and SCMC (X 2 ) were selected as the factors, which were studied at five levels each.…”

Section: Experimental Designmentioning

confidence: 99%

“…Twodimensional contour and three-dimensional surface plots were also drawn for each response variable, depending on the respective polynomial model. These plots served as a very good tool for analyzing the interaction effects of the studied dependent variables (Shah et al, 2009;Mandal et al, 2007).…”

Section: Optimization Of Statistical Data Analysismentioning

confidence: 99%

See 2 more Smart Citations

Formulation and in vitro evaluation of mucoadhesive controlled release matrix tablets of flurbiprofen using response surface methodology

Khalid¹,

Ahmad²,

Minhas³

et al. 2014

Braz. J. Pharm. Sci.

View full text Add to dashboard Cite

The objective of the current study was to formulate mucoadhesive controlled release matrix tablets of flurbiprofen and to optimize its drug release profile and bioadhesion using response surface methodology. Tablets were prepared via a direct compression technique and evaluated for in vitro dissolution parameters and bioadhesive strength. A central composite design for two factors at five levels each was employed for the study. Carbopol 934 and sodium carboxymethylcellulose were taken as independent variables. Fourier transform infrared (FTIR) spectroscopy studies were performed to observe the stability of the drug during direct compression and to check for a drug-polymer interaction. Various kinetic models were applied to evaluate drug release from the polymers. Contour and response surface plots were also drawn to portray the relationship between the independent and response variables. Mucoadhesive tablets of flurbiprofen exhibited non-Fickian drug release kinetics extending towards zero-order, with some formulations (F3, F8, and F9) reaching super case II transport, as the value of the release rate exponent (n) varied between 0.584 and 1.104. Polynomial mathematical models, generated for various response variables, were found to be statistically significant (P<0.05). The study also helped to find the drug's optimum formulation with excellent bioadhesive strength. Suitable combinations of two polymers provided adequate release profile, while carbopol 934 produced more bioadhesion.Uniterms: Flurbifrofen/mucoadhesive controlled release tablets/formulation. Flurbifrofen/mucoadhesive controlled release tablets/in vitro evaluation. Drugs/release profile. Drugs/bioadhesion. Tablets/direct compression.O objetivo do presente estudo foi formular comprimidos mucoadesivos de flurbiprofeno, de liberação controlada, e otimizar o perfil da liberação do fármaco e a bioadesão, utilizando a metodologia de superfície de resposta. Prepararam-se os comprimidos via técnica de compressão direta, que foram avaliados in vitro quanto aos parâmetros de dissolução e da força bioadesiva. Planejamento com componente central para dois fatores em cinco níveis cada foi empregado para esse estudo. Carbopol 934 e carboximetilcelulose sódica foram tomados como variáveis independentes. Efetuaram-se estudos de espectroscopia por transformada de Fourier (FTIR) para observar a estabilidade do fármaco durante a compressão direta e para avaliar a interação a fármaco-polímero. Aplicaram-se vários métodos cinéticos para avaliar a liberação do fármaco dos polímeros. Gráficos de superfície de contorno e de resposta foram efetuados para retratar a relação entre as variáveis dependentes e a resposta. Os comprimidos mucoadesivos de flurbiprofeno apresentaram cinética de liberação não-fickiana, estendendo para ordem zero, para algumas formulações (F3, F8 e F9), alcançando transporte super caso II, à medida que o valor do expoente (n) de taxa de liberação variou entre 0,584 e 1,104. Modelos matemáticos polinomiais, gerados por diversas variáveis de resposta, ...

show abstract

Section: Fourier Transform Infrared Spectroscopysupporting

confidence: 91%

Section: Experimental Designmentioning

confidence: 99%

See 1 more Smart Citation

Formulation and in vitro evaluation of mucoadhesive controlled release matrix tablets of flurbiprofen using response surface methodology

Khalid¹,

Ahmad²,

Minhas³

et al. 2014

Braz. J. Pharm. Sci.

View full text Add to dashboard Cite

show abstract

“…Such a behavior of dosage form effectively minimizes side effects and subsequently improves tolerability and adherence. Many researchers have sought to formulate matrices for zero-order release pattern, but few have been successful (25,40).…”

Section: Discussionmentioning

confidence: 99%

Controlled Release Matrix Tablets of Olanzapine: Influence of Polymers on the In Vitro Release and Bioavailability

2010

View full text Add to dashboard Cite

Abstract. Controlled-release (CR) tablet formulation of olanzapine was developed using a binary mixture of Methocel® K100 LV-CR and Ethocel® standard 7FP premium by the dry granulation slugging method. Drug release kinetics of CR tablet formulations F1, F2, and F3, each one suitably compressed for 9-, 12-, and 15-kg hardness, were determined in a dissolution media of 0.1 N HCl (pH 1.5) and phosphate buffer (pH 6.8) using type II dissolution apparatus with paddles run at 50 rpm. Ethocel® was found to be distinctly controlling drug release, whereas the hardness of tablets and pH of the dissolution media did not significantly affect release kinetics. The CR test tablets containing 30% Methocel® and 60% Ethocel® (F3) with 12-kg hardness exhibited pH-independent zero-order release kinetics for 24 h. In vivo performance of the CR test tablet and conventional reference tablet were determined in rabbit serum using high-performance liquid chromatography coupled with electrochemical detector. Bioavailability parameters including C max , T max , and AUC 0-48 h of both tablets were compared. The CR test tablets produced optimized C max and extended T max (P<0.05). A good correlation of drug absorption in vivo and drug release in vitro (R 2 =0.9082) was observed. Relative bioavailability of the test tablet was calculated as 94%. The manufacturing process employed was reproducible and the CR test tablets were stable for 6 months at 40±2°C/75±5% relative humidity. It was concluded that the CR test tablet formulation successfully developed may improve tolerability and patient adherence by reducing adverse effects.

show abstract

“…It reduces the number of experimental runs necessary to establish a mathematical trend in the experimental design allowing for the determination of the optimum level. Reducing the number of experiments by optimizing a formulation during development of a drug delivery device may also lead to significant reductions in production costs (20).…”

Section: Figurementioning

confidence: 99%

Applying response surface methodology to optimize nimesulide permeation from topical formulation

Shahzad¹,

Afreen²,

Shah³

et al. 2012

Pharmaceutical Development and Technology

View full text Add to dashboard Cite

Nimesulide is a non-steroidal anti-inflammatory drug that acts through selective inhibition of COX-2 enzyme. Poor bioavailability of this drug may leads to local toxicity at the site of aggregation and hinders reaching desired therapeutic effects. This study aimed at formulating and optimizing topically applied lotions of nimesulide using an experimental design approach, namely response surface methodology. The formulated lotions were evaluated for pH, viscosity, spreadability, homogeneity and in vitro permeation studies through rabbit skin using Franz diffusion cells. Data were fitted to linear, quadratic and cubic models and best fit model was selected to investigate the influence of permeation enhancers, namely propylene glycol and polyethylene glycol on percutaneous absorption of nimesulide from lotion formulations. The best fit quadratic model explained that the enhancer combination at equal levels significantly increased the flux and permeability coefficient. The model was validated by comparing the permeation profile of optimized formulations' predicted and experimental response values, thus, endorsing the prognostic ability of response surface methodology.

show abstract

Formulation and evaluation of natural gum-based sustained release matrix tablets of flurbiprofen using response surface methodology

Abstract: The formulated matrix tablets followed zero-order kinetics with negligible drug release in 0.1 N HCl at pH 1.2, which was the objective of this study to produce a formulation avoiding the gastric effects of flurbiprofen.

Cited by 41 publications

References 15 publications

Formulation and in vitro evaluation of mucoadhesive controlled release matrix tablets of flurbiprofen using response surface methodology

Formulation and in vitro evaluation of mucoadhesive controlled release matrix tablets of flurbiprofen using response surface methodology

Controlled Release Matrix Tablets of Olanzapine: Influence of Polymers on the In Vitro Release and Bioavailability

Applying response surface methodology to optimize nimesulide permeation from topical formulation

Contact Info

Product

Resources

About