Formulation and Evaluation of Liquid Oral Suspension of Paracetamol Using Newly Isolated and Characterized Hygrophila Spinosa Seed Mucilage as Suspending Agent

Krishna, Anjali; Mohanan, Shan

doi:10.22159/ajpcr.2018.v11i11.28856

Cited by 3 publications

(1 citation statement)

References 7 publications

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“…This compound is a calcium channel blocker that is used for the treatment of angina pectoris and hypertension, particularly in pediatric and geriatric patients. It is highly protein bound 70-90% and undergoes extensive first-pass metabolism with relatively poor oral bioavailability of 40% [7]. We selected this drug as an active agent because it is compatible with suspending vehicles, which are intended for the treatment of pediatric and geriatric patients [8].…”

Section: Introductionmentioning

confidence: 99%

Formulation of Suspending Vehicles for Extemporaneous Oral Liquid Compounding With Diltiazem Hydrochloride as a Drug Model

Sutriyo

Nisa

2018

Int J App Pharm

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Objective: This study aimed to determine the optimum concentrations of a suspending vehicle and develop a physically and chemically stableformulation containing diltiazem hydrochloride (DTZ).Methods: Stability testing was performed for 30 days in selected suspending vehicle formulas (Formulas A and E). Physical stability tests wereperformed at room temperature, and physical properties (odor and color) and pH values of suspensions were evaluated.Results: The oral suspensions of DTZ were white and had a drug-like odor, and the pH had significantly decreased during storage. Chemical stabilitytests of suspensions were performed at room temperature and 4°C±2°C using ultraviolet-visible spectrophotometry.Conclusion: The concentrations of DTZ in oral suspensions fluctuated during the storage period, suggesting that the oral suspensions of DTZ arephysically stable but not chemically stable during storage.

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Section: Introductionmentioning

confidence: 99%

Formulation of Suspending Vehicles for Extemporaneous Oral Liquid Compounding With Diltiazem Hydrochloride as a Drug Model

Sutriyo

Nisa

2018

Int J App Pharm

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Formulation and Pharmaceutical Assessment of Annona muricata Oral Capsules and Suspension as Antidiarrhea Dosage Forms

Owusu

Boakye-Gyasi

Entsie

et al. 2021

Journal of Chemistry

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Annona muricata (Annonaceae) is a tropical plant widely known for its edible fruits. Recent scientific studies have confirmed the folkloric use of its seeds as an antidiarrheal agent. This study sought to formulate capsules and suspensions using the ethanolic extract from Annona muricata seeds. The dried ethanolic extract was formulated into granules and subsequently encapsulated. The suspension formulated was assessed for sedimentation rate, sedimentation volume, viscosity, dissolution, drug content, and flow rate, while pharmacopeia tests such as disintegration, dissolution, uniformity of weight, and drug content were carried out on the formulated capsules. The formulated suspension passed the drug content and in vitro release studies. Annona muricata suspension exhibited pseudoplastic flow with good sedimentation rate and sedimentation volume. The formulated capsules passed the in vitro dissolution studies, weight uniformity, disintegration, and drug content tests. The ethanolic extract of Annona muricata seeds was appropriately formulated into standardized solid and liquid oral dosage forms.

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Formulation and In Vitro Evaluation of Oral Capsules and Suspension from the Ethanolic Extract of Cola nitida Seeds for the Treatment of Diarrhea

Owusu

Asare

Enstie

et al. 2021

BioMed Research International

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Management of diarrhea has evolved over the years from relatively inadequate interventions in the early years to more successful physiological approaches. The use of herbal medicinal products and supplements has grown significantly over the past three decades, with more than half of the global population depending on it for some aspect of their primary health care needs. This study is aimed at formulating solid and liquid oral dosage forms of the ethanolic extract of Cola nitida seeds for the treatment of diarrhea. The flow property of the dried ethanolic extract was determined and subsequently formulated into granules for encapsulation. The ethanolic extract was also used in formulating an oral suspension. Pharmacopeia tests such as uniformity of weight, disintegration, drug content, and dissolution were carried out on the formulated capsules. The formulated suspension was also assessed using the following parameters; viscosity, flow rate, drug content, dissolution, sedimentation rate, and sedimentation volume. The dried ethanolic extract and formulated granules exhibited good flow properties. The formulated capsules exhibited optimal in vitro release of extract (>90% after 45 minutes) and passed the uniformity of weight, disintegration, and drug content tests. The formulated suspension also passed the drug content test and had a good sedimentation rate, sedimentation volume, and flow rate. The formulated suspension also exhibited pseudoplastic flow, optimal viscosity, and a good in vitro release profile (>90% after 45 minutes). Capsules and suspension of the ethanolic extract of Cola nitida seeds have been successfully formulated and can be used as standard dosage forms for the management of diarrhea.

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Formulation and Evaluation of Liquid Oral Suspension of Paracetamol Using Newly Isolated and Characterized Hygrophila Spinosa Seed Mucilage as Suspending Agent

Cited by 3 publications

References 7 publications

Formulation of Suspending Vehicles for Extemporaneous Oral Liquid Compounding With Diltiazem Hydrochloride as a Drug Model

Formulation of Suspending Vehicles for Extemporaneous Oral Liquid Compounding With Diltiazem Hydrochloride as a Drug Model

Formulation and Pharmaceutical Assessment of Annona muricata Oral Capsules and Suspension as Antidiarrhea Dosage Forms

Formulation and In Vitro Evaluation of Oral Capsules and Suspension from the Ethanolic Extract of Cola nitida Seeds for the Treatment of Diarrhea

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