Formulation and Evaluation of Gastroretentive Dosage Form of Ofloxacin

Veerareddy, Prabhakar Reddy; Bajjuri, Spandana; Sanka, Krishna; Jukanti, Raju; Bandari, Suresh; Ajmeru, RK; Potu, Appa Rao

doi:10.3329/sjps.v4i1.8861

Cited by 8 publications

(4 citation statements)

References 27 publications

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“…it can be observed that both polymers polyethylene Oxide (PEO)(X1) and Carbopol 940 P (X2) have a significant effect on floating lag time. Moreover, the effect of the polymer Carbopol 940 P had significantnegative effect of on the floating lag times means increase Carbopol 940 amount (X2) will be accompanied by significant reduction in the floating lag times it might be due to the hydrophilic nature of Carbopol 940P produces faster medium penetration rate, and thus, shorter time for gel layer formation these findings are similar to what has been reported by [36].…”

Section: Fig 3: a Response Surface Plot Showing Effect Of Concentration Of Independent Variables On The Floating Lag Timesupporting

confidence: 82%

Design Expert Supported Formulation Development, Mathematical Optimization and Predictability Study of Floating Tablets of Bisoprolol Fumarate

Ahmad

Siraj²,

Siddik³

et al. 2021

Int J App Pharm

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Objective: Focus of the study was to formulate Design expert Software assisted floating tablet of Bisoprolol Fumarate. Bisoprolol Fumarate is a Beta adrenergic blocking agent, used to treat cardiac diseases favorable characters to be formulated as sustained release Gastro retentive floating tablets. Methods: Floating Tablets of Bisoprolol Fumarate were prepared by using polymers such as Polyox N 12 K and Carbapol 940 P. Formulations were prepared by using direct compression method and evaluated for various parameters like Hradness, thickness, weight variations, Floating lag time Total floating time,% drug release and Stability Study etc. Results: FTIR spectroscopic study indicates no drug-excipients interaction in the prepared formulations. Hardness or crushing strength of the tablets of all the formulation was found between 5.8 and 6.5 kg/cm2. Floating lag time of all batches is in range of 1.18±2.0 to 2.43±1.6 (minutes). All other parameters of all batches are within an acceptable range. The polymer Carbopol 940 P had the significant negative effect of on the floating lag times. The In vitro dissolution profiles of optimized A3 Floating formulation of Bisoprolol Fumarate were found to sustain drug release 99.25 % up to 12 h with floating lag time of 1.45 min; Designed formulation was stable after Stability study. Optimization study was carried out by using 32 factorial designs to fabricate formulations. Conclusion: It can be conclude that reproducible results of various parameters in this developed formulation can easily scale up. Furthermore designed formulation will be very effective for controlling blood pressure.

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Section: Fig 3: a Response Surface Plot Showing Effect Of Concentration Of Independent Variables On The Floating Lag Timesupporting

confidence: 82%

Design Expert Supported Formulation Development, Mathematical Optimization and Predictability Study of Floating Tablets of Bisoprolol Fumarate

Ahmad

Siraj²,

Siddik³

et al. 2021

Int J App Pharm

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“…The release studies were performed in triplicate, and the mean values were plotted versus time. Each sample was analyzed at 293nm using double beam UV -Visible Spectrophotometer against reagent blank [22].…”

Section: 8 In Vitro Drug Release Studiesmentioning

confidence: 99%

Sustain Release Formulation and Evaluation of Ofloxacin Floating Delivery System

Patel

Naik

Raval

2014

ILCPA

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Floating tablets has been accepted as a process to achieve controlled drug delivery by prolonging the residence time of the dosage form at the site of absorption, thereby improving and enhancing the bioavailability of drug. The objective of present study outlines the development and characterization the floating drug delivery system of Ofloxacin to enhance its bioavailability and therapeutic efficacy, using different grades of polymer along with effervescent agent sodium bicarbonate and citric acid. Ofloxacin is a synthetic chemotherapeutic second-generation antibiotic of the fluoroquinolone class. Different tablet formulations were formulated by wet granulation technique and were evaluated for physical parameters like Tablet Thickness, Hardness, % Friability, Weight variation, Content uniformity, In vitro buoyancy, Swelling index, In vitro dissolution study and drug release mechanisms. As the concentration of the polymer in the formulations increased the release of drug decreased. Hence it was considered as suitable candidate for formulation as floating drug delivery system. Different kinetic models were applied to drug release data in order to evaluate release mechanisms and kinetics. The optimized formula F4 showed better sustained drug release with good floating properties and fitted best to be Korsmeyer-Peppas model with R 2 value of 0.9575. As the n value for the Korsmeyer-Peppas model was found be more than 0.5 it follows Non-Fickian diffusion mechanism. FTIR result showed that there is no drug excipients interaction.

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“…This type of drug delivery method would have comparatively less side effect and would eliminate the need for repeated dosages. 4 In pharmaceutical dosage, the formulation of drugs in multilayered / bi-layered tablets is a innovative approach for providing the loading dose and maintenance dose in a tablet. This design allows for the preparation of extended release with an immediate release quantity of drug in one layer and an extended release proportion in the second, thereby retaining a prolonged blood level.…”

Section: Introductionmentioning

confidence: 99%

Floating Drug Delivery System: A Brief Review

Lodh¹,

FR²,

Chourasia³

et al. 2020

AJPTR

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Scientific and technological developments in the research and development of new drug delivery systems have been made in recent years by resolving physiological disorders, such as short gastric residence periods and unpredictable gastric emptying times. Dosage forms that can be hold within the stomach are called as Gastro-retentive Dosage Forms (GRDF). Multiple methods used in the prolongation of gastric residence time are floating drug delivery system, swelling and expanding system, polymeric bio-adhesive system, high density system and other delayed gastric emptying system. Medication-based disease treatment is entering a new era in which a increasing range of innovative drug delivery technologies are being used and are available for clinical use. Floating Drug Delivery Systems (FDDS) is one of the gastro-retentive dosage forms used to achieve extended duration of gastric residency. The aim of writing this review on floating drug delivery systems (FDDS) was to compile the recent literature with particular focus on the main floating mechanism to achieve gastric retention. Sustained oral release of gastrointestinal dosage types provides many benefits for drugs with absorption from the upper sections of the gastrointestinal tract and those that function locally throughout the stomach. This review includes the physiology, factors controlling gastric retention time, excipient variables influencing gastric retention, approaches to designing single-unit, hydro-dynamically balanced system and multi-unit floating structure, and aspects of their classification, formulation and evaluation are discussed in detail, and few applications of these systems.

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Formulation and Evaluation of Gastroretentive Dosage Form of Ofloxacin

Cited by 8 publications

References 27 publications

Design Expert Supported Formulation Development, Mathematical Optimization and Predictability Study of Floating Tablets of Bisoprolol Fumarate

Design Expert Supported Formulation Development, Mathematical Optimization and Predictability Study of Floating Tablets of Bisoprolol Fumarate

Sustain Release Formulation and Evaluation of Ofloxacin Floating Delivery System

Floating Drug Delivery System: A Brief Review

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